Alta Sciences

AUGUST 9, 2023

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Cell Based Assays 40

Cell Based Assays Vaccine Therapies Drugs 40

Molecular Design

NOVEMBER 19, 2023

To gain insight into the use of chemical probes, we conducted a systematic review of 662 publications, understood here as primary research articles, employing eight different chemical probes in cell-based research. [

Cell Based Assays 73

Cell Based Assays Research Compliance Laboratories 73

Drug Target Review

JULY 25, 2023

The perennial challenge with STING-seq (and all cell-based assays) is finding the right cell type for the disease or trait. This encompasses many common diseases and we are optimistic that STING-seq will be a useful platform to rapidly understand which variants and genes are key players in these diseases.

Cell Based Assays 98

Cell Based Assays Disease Therapies Science 98

PerkinElmer

AUGUST 13, 2020

Following the high-throughput screening were cell-based assays, which demonstrated that the identified leads had strong anti-viral action. Of these 10,000 compounds, some were drugs already approved for other uses; others were drug candidates being used in clinical trials. Still others were simply known inhibitors of Mpro.

Virus 52

Virus Cell Based Assays FDA Approval Clinical Trials 52

The Pharma Data

JANUARY 6, 2021

Dr. Pepe has a PhD in cancer biology and DNA repair and extensive experience in development and validation of cell-based assays. Alessandra Pepe, AD Processes and Infrastructure Manager at Merck Group.

Cell Based Assays 52

Cell Based Assays Compound Screening Organic Chemistry DNA 52

The Pharma Data

JANUARY 12, 2021

CAMBRIDGE, England–( BUSINESS WIRE )– Axol Bioscience , a biotechnology company specializing in the use of stem cell technology to manufacture disease relevant cell based assay systems to the drug discovery industry, today announced the appointment of Ross Wheatcroft as the Global Strategic Accounts Manager.

Cell Based Assays 40

Cell Based Assays Science Production Marketing 40

Drug Target Review

OCTOBER 24, 2024

Data-driven discovery As with many early-stage biotech companies, Five Alarm Bio is highly data-driven, producing vast amounts of experimental data through cell-based assays and phenotypic screening.

Cell Based Assays 52

Cell Based Assays Science Disease Doctors 52

The ChEMBL-og

SEPTEMBER 1, 2021

Finally, ChEMBL version 27 was a special SARS-CoV-2 release focused on large-scale drug screening studies for anti-viral activity, in particular cell-based assays with well-characterised compounds. Currently, there are ~ 950 K activities for Plasmodium species alone.

Cell Based Assays 52

Cell Based Assays Screening Hits Small Molecule Virus 52

Broad Institute

JUNE 30, 2023

Image analysis software captures information about more than 3,000 cellular features, providing a deep view into the impacts of genetic variants, small molecule or genetic perturbations, and more on cellular shape, structure, and function. “It moves the community from a very targeted, hypothesis-driven, unidimensional cell-based assay framework to (..)

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105

The ChEMBL-og

OCTOBER 12, 2020

ChEMBL contains a broad range of binding, functional and ADMET type assays in formats ranging from in vitro single protein assays to anti proliferative cell-based assays. Some variation is expected, even for very similar assays, since these are often performed by different groups and institutes.

Cell Based Assays 52

Cell Based Assays Drugs 52

Broad Institute

JUNE 21, 2023

When combined with CellProfiler (a machine learning-based image profiling application), LipocyteProfiler can reveal information about more than 3,000 cellular features, providing a deep view into the impacts of genetic variants, small molecule or genetic perturbations, and more on cell shape, structure, and function. “It moves the community from (..)

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

PerkinElmer

JANUARY 7, 2020

There has been a resurgence of interest in the development of small molecules modulating kinases and of antibodies to cell surface receptors, guided by the selection of molecules having the longest residence time, as this is a key factor to the specificity and real efficacy of new therapeutics.

Small Molecule 52

Small Molecule Cell Based Assays Drugs Drug Development 52

The ChEMBL-og

APRIL 16, 2024

University of Dundee: T. 1813 bioactivities in total have been added.

Clinical Trials 108

Clinical Trials FDA Cell Based Assays Compound Screening 108

FDA Law Blog: Drug Discovery

FEBRUARY 2, 2023

The definition goes on to list potential options for such tests: cell-based assays, organ chips and microphysiological systems, computer modeling, other nonhuman or human biology-based test methods such as bioprinting, as well as animal tests. FDORA § 3209(a)(2).

Animal Testing 64

Animal Testing Biosimilars Cell Based Assays FDA 64

Drug Target Review

JULY 6, 2023

allowing researchers to use “certain alternatives to animal testing, including cell-based assays and computer models, to obtain an exemption from the FDA to investigate the safety and effectiveness of a drug.”

Animal Testing 105

Animal Testing Drugs Clinical Trials Clinical Research 105

The Premier Consulting Blog

APRIL 3, 2024

Technology Selection Description of which technology was selected (HPLC, SDS-PAGE, cell-based assay, ELISA, etc.) and a rationale for selecting it (could be based on development studies, prior knowledge, literature, etc.).

Pharmaceuticals 52

Pharmaceuticals Cell Based Assays Production International 52

Molecular Design

JUNE 8, 2023

I would argue that the L2021 study has absolutely no relevance whatsoever to the selection of compounds for development since the team will have data available that enables them to rule out the vast majority of the project compounds for nomination.

Cell Based Assays 64

Cell Based Assays Small Molecule Drugs Clinical Development 64

Molecular Design

DECEMBER 19, 2023

Regardless of whether binding to target is covalent or non-covalent, the concentration and affinity of substrates (as well as cofactors such as ATP) need be properly accounted for when interpreting effects of chemical probes in cell-based assays. As measurement of k.inact/K.i

Small Molecule 66

Small Molecule Biochemical Assays Cell Based Assays Drugs 66

Elrig

APRIL 29, 2024

Inspired by her time at GSK, Millie pursued a PhD at the University of Cambridge investigating the signalling pathways that drive cancer cell growth using in-vitro cell based assays and biochemical analysis. Driven by an interest in drug discovery Millie joined AstraZeneca after completion of her PhD at the end of 2020.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Molecular Design

DECEMBER 31, 2023

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs 98

Drugs Packaging Cell Based Assays Small Molecule 98

The Pharma Data

OCTOBER 15, 2020

ASLAN003 is a highly selective and potent inhibitor of human DHODH (IC 50 = 35 nM) and has been shown to be more than 30 times more potent at inhibiting the DHODH enzyme in cell free and cell-based assays than the first generation inhibitor teriflunomide.

Pharmaceuticals 40

Pharmaceuticals Cell Based Assays Clinical Development Treatment 40

Molecular Design

SEPTEMBER 18, 2024

Different assay organism or cell types: the target protein may be recombinantly expressed in different cell types (the target ID in ChEMBL is assigned based on the original source of the target), or the assays may be run using different cell types.

Biochemical Assays 69

Biochemical Assays Biophysical Assays Drugs Cell Based Assays 69

Molecular Design

MARCH 26, 2024

For example, we might examine the structure-activity relationship in a cell-based assay for consistency with the structure-activity relationship that we’ve observed in the enzyme inhibition assay. We have to make assumptions in these situations and we also need to check that these assumptions are reasonable.

Drugs 79

Drugs Pharmacokinetics Cell Based Assays Treatment 79

Tebu Bio: Drug Discovery

APRIL 24, 2020

Recombinant monoclonal antibody (mAB) based treatments have proven their efficacy. mRNA vaccines are developing very quickly with dozens of ongoing clinical trials against cancers or infectious diseases (e.g. HIV or more recently SARS-Cov-2).

Vaccine 52

Vaccine Clinical Trials RNA Trials 52

BMG Labtech

MARCH 8, 2023

An active metabolism is a sign of viable cells and can be hence exploited by viability assays (fig.12) In addition, ATP is used as fuel by many luciferase-based assays.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production 40

Production FDA Therapies Biochemical Assays 40

The Pharma Data

JANUARY 24, 2021

Endeavor revolutionizes drug discovery by delivering high speed, high resolution, full well scanning of cell-based assays. Endeavor images 10 times the biology in a fraction of the time, acquiring every cell, every time. This press release features multimedia. View the full release here: [link].

Cell Based Assays 52

Cell Based Assays Laboratories Science Production 52

Drug Target Review

MAY 3, 2024

At Beckman Coulter Life Sciences , he supports the applications development team in NGS, cell-based assays, and proteomics workflows.

Research 116

Research Science Cell Based Assays Disease 116