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Transforming high-throughput screening with mass spectrometry

Drug Discovery World

Trapped ion mobility spectrometry: Improving the specificity of MALDI-MS-based HTS . The ability of MALDI-enabled TOF and QTOF systems to discriminate between analytes and sample matrix background components based on their specificity is, like other MS techniques, dependent upon the mass resolution. References . Attene-Ramos and M.

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Flow cytometry technologies and cancer associated fibroblasts

Drug Discovery World

Flow cytometry is a high- throughput, cell-based assay used to examine properties of single cells. It has been used to investigate rare cell populations, screen potential drug therapeutics, and examine sample phenotypes for diagnostic applications 2. Mass Cytometry: Single Cells, Many Features. 2016.04.019.

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Measure Cell Metabolism with Microplate Readers | BMG LABTECH

BMG Labtech

An active metabolism is a sign of viable cells and can be hence exploited by viability assays (fig.12) In addition, ATP is used as fuel by many luciferase-based assays. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press. Freeze HH, Glycosylation Precursors. Essentials of Glycobiology (3rd ed.).