Re-assessing the risks of drug-induced arrhythmias during drug discovery
Drug Discovery World
AUGUST 15, 2023
Figure 1: A diagrammatic representation of paced electrogram fractionation analysis (PEFA) as carried out in patients in a typical hospital setting. However, many other drugs exhibit a more complex multichannel pharmacology 7 , which is much harder to interpret and cannot be easily modelled by screening against a single ion channel.
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