Drug Target Review

OCTOBER 24, 2024

Janette Thomas leads a small biotech company (Five Alarm Bio) 1 on a mission to develop drugs targeting the chronic diseases associated with ageing. Her company’s focus includes dementia, muscle wasting, and chronic wounds – diseases that disproportionately affect the elderly. Reference 1 Five Alarm Bio. cited 2024 Oct 17].

Cell Based Assays 52

Cell Based Assays Science Disease Doctors 52

Drug Target Review

JULY 6, 2023

allowing researchers to use “certain alternatives to animal testing, including cell-based assays and computer models, to obtain an exemption from the FDA to investigate the safety and effectiveness of a drug.” Three-dimensional organoids have been a popular choice in testing drugs to treat cancer and disease.

Animal Testing 105

Animal Testing Drugs Clinical Trials Clinical Research 105

The Pharma Data

OCTOBER 15, 2020

ASLAN believes ASLAN003 has the potential to bethe most potent oral inhibitor of DHODH currently in development for autoimmune disease, more than 30 times more potent at inhibiting the DHODH enzyme than teriflunomide. In preclinical studies, ASLAN003 was shown to be efficacious in animal models of MS and other autoimmune diseases.

Pharmaceuticals 40

Pharmaceuticals Cell Based Assays Clinical Development Treatment 40

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production 40

Production FDA Therapies Biochemical Assays 40

Drug Target Review

MAY 3, 2024

This is especially true in domains such as protein structure, predictive binding kinetics, and even in larger systemic investigations like cell migration models or disease progression. Ultimately, multi-omics represents an opportunity to generate high-fidelity, richly informative datasets that are often internally orthogonal.

Research 116

Research Science Cell Based Assays Disease 116