ASPET

AUGUST 10, 2023

In cell-based assays, pegozafermin had a similar receptor engagement profile as native FGF21, with approximately 8-fold higher potency at FGF receptor 1 (FGFR1). These findings provide evidence that pegozafermin is a promising candidate molecule for the treatment of patients with NASH or SHTG.

Cell Based Assays 100

Cell Based Assays Pharmacokinetics Regulations Treatment 100

ASPET

SEPTEMBER 15, 2023

Mirikizumab effectively inhibits the interaction of IL-23 with its receptor, and potently blocks IL-23-induced IL-17 production in cell-based assays while preserving the function of IL-12. In both local and systemic in vivo mouse models, mirikizumab blocked IL-23-induced keratin mRNA or IL-17 production, respectively.

Cell Based Assays 100

Cell Based Assays Clinical Trials Disease Production 100

Drug Target Review

JULY 25, 2023

Co-led by Dr Sanjana, the research study combines CRISPR gene editing and single-cell sequencing to identify causal genetic variants and enhance our understanding of the noncoding genome. Published in Science , the study offers new possibilities for identifying therapeutic targets in genetically influenced diseases.

Cell Based Assays 98

Cell Based Assays Disease Therapies Science 98

Drug Target Review

JULY 6, 2023

allowing researchers to use “certain alternatives to animal testing, including cell-based assays and computer models, to obtain an exemption from the FDA to investigate the safety and effectiveness of a drug.” Three-dimensional organoids have been a popular choice in testing drugs to treat cancer and disease.

Animal Testing 105

Animal Testing Drugs Clinical Trials Clinical Research 105

DrugBank

FEBRUARY 12, 2025

This approach capitalizes on prior investments in R&D, mitigates risk by leveraging established safety and pharmacokinetic profiles, and accelerates the delivery of treatments to patients. For example, researchers utilized gene expression data to determine the anti-ulcer drug cimetidine as a possible treatment for colorectal cancer.

Cell Based Assays 52

Cell Based Assays Drugs Pharmacokinetics Disease 52

Alta Sciences

SEPTEMBER 27, 2024

As the complexity of these therapeutics increases, so must the sophistication of the bioanalytical assays designed to either quantify them or measure their impact on the patient. Selecting the right assay depends on the specific immunomodulator and the clinical trial’s endpoints.

Clinical Trials 52

Clinical Trials Trials Pharmacokinetics Small Molecule 52

Tebu Bio: Drug Discovery

APRIL 24, 2020

mRNA vaccines are developing very quickly with dozens of ongoing clinical trials against cancers or infectious diseases (e.g. Recombinant monoclonal antibody (mAB) based treatments have proven their efficacy. HIV or more recently SARS-Cov-2).

Vaccine 52

Vaccine Clinical Trials RNA Trials 52