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Dr. Pepe has a PhD in cancer biology and DNA repair and extensive experience in development and validation of cell-basedassays. Boehm has a PhD in Organic Chemistry from the University of Nottingham, UK. Alessandra Pepe, AD Processes and Infrastructure Manager at Merck Group.
Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing.
DNA, proteins, polysaccharides, etc.). Cells require energy for this process. 2 Organisms are categorised based on their anabolism and according to the source used by cells to build-up molecules. An active metabolism is a sign of viable cells and can be hence exploited by viability assays (fig.12)
Cell-basedassays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).
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