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New image-based cellular profiling tool peers deeply into metabolic biology

Broad Institute

The researchers also looked at the tool’s ability to detect changes in cellular phenotypes after exposure to drugs and small molecule compounds. Typically, studying drug therapies is an expensive and time-consuming undertaking.

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Expanding Your Assay Specificity: Cisbio Joins PerkinElmer

PerkinElmer

Over the last 20 years, Cisbio has become a leading Life Sciences company which develops, manufactures, and markets high quality kits and reagents for the drug discovery and life science markets used by pharmaceutical, biotechnology, academia and contract research organizations across the globe. Learn more about Cisbio here.

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Assays for the Future of Drug Discovery

PerkinElmer

Drug discovery is always evolving. From new processes to advanced technologies, excellence in drug discovery is the result of combining different approaches. Emerging and Resurrecting Technologies We’ve made huge strides in the drug discovery process, and it’s only getting better as we move forward.

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Chemical con artists foil drug discovery

Molecular Design

BW2014 has been heavily cited in the drug discovery literature (it was cited as the first reference in the ACS assay interference editorial which I reviewed in K2017 ) despite providing nothing in the way of practical advice for dealing with nuisance behavior. Given that M2003 had been published over a decade previously.

Drugs 98
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Inside The Altascientist Issue 41: Immunomodulation Assessments for Clinical Trials–Sophisticated Bioanalytical Approaches to Support Complex Modalities

Alta Sciences

This issue also covers classes of immunomodulators, including monoclonal antibodies, CAR-T cells, and vaccines; immunotherapy trials, focusing on complex study designs and diverse patient populations; and bioanalytical methods and assays, including pharmacokinetics and anti-drug antibodies (ADA).

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Pathogen data in ChEMBL

The ChEMBL-og

For example, queries may be performed to extract high level pathogen data such as all bioactivity data for small molecules screened against bacterial targets (example below) or more specific subsets focused on gram-positive pathogens or on a single bacterial species. Currently, there are ~ 950 K activities for Plasmodium species alone.

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On quality criteria for covalent and degrader probes

Molecular Design

Covalent bond formation between ligands and targets is a drug design tactic for exploiting molecular recognition elements in targets that are difficult to make beneficial contacts with. This Perspective is intended to jumpstart this important scientific discussion. Subscripting doesn't work well in blogger and so I'll use K.i