Drug Target Review

JULY 6, 2023

allowing researchers to use “certain alternatives to animal testing, including cell-based assays and computer models, to obtain an exemption from the FDA to investigate the safety and effectiveness of a drug.” Overall, there are several alternatives to animal testing that can be used in pre-clinical research.

Animal Testing 105

Animal Testing Drugs Clinical Trials Clinical Research 105

Elrig

APRIL 29, 2024

Inspired by her time at GSK, Millie pursued a PhD at the University of Cambridge investigating the signalling pathways that drive cancer cell growth using in-vitro cell based assays and biochemical analysis. Driven by an interest in drug discovery Millie joined AstraZeneca after completion of her PhD at the end of 2020.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Molecular Design

MARCH 26, 2024

To this I’d add that we often don’t use the full-length proteins in design and recombinant proteins may have been engineered to make them easier to crystallize or more robust for soaking experiments. Recombinant expression can lead to missing post-translational modifications (e.g.,

Drugs 61

Drugs Pharmacokinetics Cell Based Assays Treatment 61

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production 40

Production FDA Therapies Biochemical Assays 40