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Accelerating Drug Discovery Through Repurposing

DrugBank

This approach capitalizes on prior investments in R&D, mitigates risk by leveraging established safety and pharmacokinetic profiles, and accelerates the delivery of treatments to patients. Key techniques include high-throughput screening (HTS), cell-based assays, and animal models.

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Leadeth me unto Truth and delivereth me from those who have already found it

Molecular Design

To this I’d add that we often don’t use the full-length proteins in design and recombinant proteins may have been engineered to make them easier to crystallize or more robust for soaking experiments. In drug discovery truth may also be a compound that, despite an excellent pharmacokinetic profile, chokes comprehensively in phase 2.]

Drugs 60