PerkinElmer

AUGUST 13, 2020

For this reason, researchers around the globe are scrambling to understand this novel virus and figure out its potentially targetable vulnerabilities. Speed is of critical importance to ongoing research efforts, given the virus’ rapid spread combined with a massive worldwide shortage of appropriate ventilator equipment.

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Virus Cell Based Assays FDA Approval Clinical Trials 52

The ChEMBL-og

APRIL 16, 2024

A company research code, or Clinical Trial intervention name, is assigned if no standardised name is available. For virtual parent compounds, progress has been made towards assigning a distinct pref_name (typically based on the FDA GSRS preferred name) that differs from the child compound name. University of Dundee: T.

Clinical Trials 108

Clinical Trials FDA Cell Based Assays Compound Screening 108

Alta Sciences

OCTOBER 31, 2023

Our integrated CRO/CDMO services combine bioanalytical services with preclinical and clinical study solutions, manufacturing services, and all complementary research support services, for maximum efficiency.” This is Altasciences’ third purpose-built laboratory. All three laboratories across North America are uniformly designed and managed.

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Laboratories Clinical Pharmacology Cell Based Assays Drug Development 52

The ChEMBL-og

SEPTEMBER 1, 2021

In ChEMBL version 29, there are over 2 M bioactivity data points against fungal, bacterial or viral targets (for 460 K compounds) available for pathogen-related research. How can I find pathogen data? On the ChEMBL interface, the organism taxonomy is available as a filter that can be applied to bioactivity data.

Cell Based Assays 52

Cell Based Assays Screening Hits Small Molecule Virus 52

DrugBank

FEBRUARY 12, 2025

The journey from bench to bedside often spans over a decade, consuming billions of dollars in research and development (R&D) expenditure, with a significant probability of failure at each phase. For example, researchers utilized gene expression data to determine the anti-ulcer drug cimetidine as a possible treatment for colorectal cancer.

Cell Based Assays 52

Cell Based Assays Drugs Pharmacokinetics Disease 52

PerkinElmer

JANUARY 7, 2020

Successful researchers and companies master and use different technologies, making sure the interpretation of data does not suffer experimental or analytical bias and leads to better success rates and higher profitability for drug developers. The post Assays for the Future of Drug Discovery first appeared on PerkinElmer Blog.

Small Molecule 52

Small Molecule Cell Based Assays Drugs Drug Development 52

FDA Law Blog: Drug Discovery

FEBRUARY 2, 2023

The definition goes on to list potential options for such tests: cell-based assays, organ chips and microphysiological systems, computer modeling, other nonhuman or human biology-based test methods such as bioprinting, as well as animal tests. FDORA § 3209(a)(2).

Animal Testing 64

Animal Testing Biosimilars Cell Based Assays Clinical Trials 64

Alta Sciences

SEPTEMBER 27, 2024

For example, ELISA and multiplexed assays are used for quantifying proteins or cytokines, ELISpot is ideal for detecting antigen-specific T-cell responses, flow cytometry helps assess cell populations and functions, and cell-based assays are essential for evaluating the functional activity of immune cells.

Clinical Trials 52

Clinical Trials Trials Pharmacokinetics Small Molecule 52

Broad Institute

JUNE 21, 2023

LipocyteProfiler swaps concanavalin A, the dye that stains the ER, with BODIPY, which stains lipid droplets: fat-storing organelles that regulate lipids within every type of cell and which are particularly common in adipocytes (fat cells). Typically, studying drug therapies is an expensive and time-consuming undertaking.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

Drug Target Review

OCTOBER 24, 2024

Data-driven discovery As with many early-stage biotech companies, Five Alarm Bio is highly data-driven, producing vast amounts of experimental data through cell-based assays and phenotypic screening. As a business executive at IBM Research in New York, Dr Singh led the go-to-market for IBM Watson Genomics Analytics.

Cell Based Assays 52

Cell Based Assays Science Disease Doctors 52

Elrig

APRIL 29, 2024

Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain. Rising from Research Scientist to Senior Scientist, I supported early-stage DD efforts within their Protein Science group, based in Cambridge, UK.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Molecular Design

DECEMBER 19, 2023

However, significant efforts need to be invested into characterizing and validating covalent molecules as a prerequisite for conclusive use in biomedical research and target validation studies. As measurement of k.inact/K.i

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65

Molecular Design

DECEMBER 31, 2023

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs 96

Drugs Packaging Cell Based Assays Small Molecule 96

Tebu Bio: Drug Discovery

APRIL 24, 2020

Recombinant monoclonal antibody (mAB) based treatments have proven their efficacy. Nevertheless, researchers are now considering using messenger RNA (mRNA) technologies for the development of prophylactic and therapeutic vaccines. HIV or more recently SARS-Cov-2). Pre-clinical and clinical trials […]

Vaccine 52

Vaccine Clinical Trials RNA Trials 52

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

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Production FDA Therapies Biochemical Assays 40

The Pharma Data

JANUARY 24, 2021

Endeavor revolutionizes drug discovery by delivering high speed, high resolution, full well scanning of cell-based assays. Endeavor images 10 times the biology in a fraction of the time, acquiring every cell, every time. We develop innovative products that accelerate basic research, drug discovery, and manufacturing.

Cell Based Assays 52

Cell Based Assays Laboratories Science Production 52

Drug Target Review

MAY 3, 2024

Machine learning’s role in life sciences research As we move towards more generalised AI models, neural networks and natural language interfaces, we’re starting to see machine learning take the place of higher order reasoning and data analysis “sense making.” It’s too early to tell but I’m optimistic.

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Research Science Cell Based Assays Disease 116