Cell Based Assays and Research - Drug Discovery Digest

A covalent compound selectively inhibits RNA demethylase ALKBH5 rather than FTO

Covalent Modifiers

FEBRUARY 25, 2024

Herein, we used a targeted covalent inhibition strategy and identified a covalent inhibitor, TD19, which selectively inhibits ALKBH5 compared with FTO demethylase in protein-based and tumor cell-based assays. Moreover, TD19 displays good anticancer efficacy in acute myeloid leukemia and glioblastoma multiforme cell lines.

RNA

RNA Cell Based Assays Regulations Research

Machine learning’s growing importance in researching cells

Drug Target Review

MAY 3, 2024

Machine learning’s role in life sciences research As we move towards more generalised AI models, neural networks and natural language interfaces, we’re starting to see machine learning take the place of higher order reasoning and data analysis “sense making.” It’s too early to tell but I’m optimistic.

Research

Research Science Cell Based Assays Disease

New image-based cellular profiling tool peers deeply into metabolic biology

Broad Institute

JUNE 30, 2023

Previous Next To assess LipocyteProfiler, the researchers analyzed white and brown fat cells and liver cells, focusing on traits such as the size, the number, and the location of lipid droplets in a cell. Credit: Phil Kubitz, Claussnitzer lab A merged image showing all of the stained cellular components together.

Small Molecule

Small Molecule Cell Based Assays Disease Assay Development

Webinars

Bridging Innovation & Patient Care: The Growing Role of AI

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Genetic variant identification: unveiling the power of STING-seq

Drug Target Review

JULY 25, 2023

Co-led by Dr Sanjana, the research study combines CRISPR gene editing and single-cell sequencing to identify causal genetic variants and enhance our understanding of the noncoding genome. The perennial challenge with STING-seq (and all cell-based assays) is finding the right cell type for the disease or trait.

Cell Based Assays

Cell Based Assays Disease Therapies Science

Expanding Your Assay Specificity: Cisbio Joins PerkinElmer

PerkinElmer

SEPTEMBER 8, 2019

Following the announcement that PerkinElmer has acquired Cisbio Bioassays , here is a little more information about the exciting opportunities this brings to life sciences researchers. The company notably developed a proprietary HTRF ® technology which is a type of TR-FRET assay used in Life Sciences. Learn more about Cisbio here.

Cell Based Assays

Cell Based Assays Small Molecule Science Pharmaceuticals

Altasciences Completes Expansion of New State-Of-The-Art Laboratory in Columbia, Missouri

Alta Sciences

OCTOBER 31, 2023

Our integrated CRO/CDMO services combine bioanalytical services with preclinical and clinical study solutions, manufacturing services, and all complementary research support services, for maximum efficiency.” This is Altasciences’ third purpose-built laboratory. All three laboratories across North America are uniformly designed and managed.

Laboratories

Laboratories Clinical Pharmacology Cell Based Assays Drug Development

Accelerating Drug Discovery Through Repurposing

DrugBank

FEBRUARY 12, 2025

The journey from bench to bedside often spans over a decade, consuming billions of dollars in research and development (R&D) expenditure, with a significant probability of failure at each phase. For example, researchers utilized gene expression data to determine the anti-ulcer drug cimetidine as a possible treatment for colorectal cancer.

Cell Based Assays

Cell Based Assays Drugs Pharmacokinetics Disease

Assays for the Future of Drug Discovery

PerkinElmer

JANUARY 7, 2020

Successful researchers and companies master and use different technologies, making sure the interpretation of data does not suffer experimental or analytical bias and leads to better success rates and higher profitability for drug developers. The post Assays for the Future of Drug Discovery first appeared on PerkinElmer Blog.

Small Molecule

Small Molecule Cell Based Assays Drugs Drug Development

Separating the Hype from the Hyperbole Surrounding FDORA’s Alternatives to Animal Testing under the FD&C Act

FDA Law Blog: Drug Discovery

FEBRUARY 2, 2023

The definition goes on to list potential options for such tests: cell-based assays, organ chips and microphysiological systems, computer modeling, other nonhuman or human biology-based test methods such as bioprinting, as well as animal tests. FDORA § 3209(a)(2).

Animal Testing

Animal Testing Biosimilars Cell Based Assays FDA

tk

Broad Institute

JUNE 21, 2023

LipocyteProfiler swaps concanavalin A, the dye that stains the ER, with BODIPY, which stains lipid droplets: fat-storing organelles that regulate lipids within every type of cell and which are particularly common in adipocytes (fat cells). Typically, studying drug therapies is an expensive and time-consuming undertaking.

Small Molecule

Small Molecule Cell Based Assays Medical Schools Disease

An industry leader’s perspective on the complexity of scientific data

Drug Target Review

OCTOBER 24, 2024

Data-driven discovery As with many early-stage biotech companies, Five Alarm Bio is highly data-driven, producing vast amounts of experimental data through cell-based assays and phenotypic screening. As a business executive at IBM Research in New York, Dr Singh led the go-to-market for IBM Watson Genomics Analytics.

Cell Based Assays

Cell Based Assays Science Disease Doctors

AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Elrig

APRIL 29, 2024

Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain. Rising from Research Scientist to Senior Scientist, I supported early-stage DD efforts within their Protein Science group, based in Cambridge, UK.

Bioinformatics

Bioinformatics Drugs Molecular Biology Cell Based Assays

On quality criteria for covalent and degrader probes

Molecular Design

DECEMBER 19, 2023

However, significant efforts need to be invested into characterizing and validating covalent molecules as a prerequisite for conclusive use in biomedical research and target validation studies. As measurement of k.inact/K.i

Small Molecule

Small Molecule Biochemical Assays Cell Based Assays Drugs

Chemical con artists foil drug discovery

Molecular Design

DECEMBER 31, 2023

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs

Drugs Packaging Cell Based Assays Small Molecule

How are mRNA vaccines changing drug discovery?

Tebu Bio: Drug Discovery

APRIL 24, 2020

Recombinant monoclonal antibody (mAB) based treatments have proven their efficacy. Nevertheless, researchers are now considering using messenger RNA (mRNA) technologies for the development of prophylactic and therapeutic vaccines. HIV or more recently SARS-Cov-2). Pre-clinical and clinical trials […]

Vaccine

Vaccine Clinical Trials RNA Trials

Article FDA Thank You Draft guidance on potency assays for CGT products garners extensive stakeholder input

Agency IQ

APRIL 12, 2024

Cell-based assays , while more complex to develop and use, offer another option for characterizing product activity at a slightly higher level, allowing sponsors to measure the further downstream effects of products (e.g., morphological cell changes or alterations in protein production or expression).

Production

Production FDA Therapies Biochemical Assays

Exploring alternatives to animal testing in drug discovery

Drug Target Review

JULY 6, 2023

Animal testing plays a significant role in pre-clinical research and therefore requires the use of millions of animals. 1 Over a quarter of those were for basic research purposes, with most common areas focused on the immune system, the nervous system and oncology. These cell cultures can be used to mimic aspects of human physiology.

Animal Testing

Animal Testing Drugs Clinical Trials Clinical Research

On the misuse of chemical probes

Molecular Design

NOVEMBER 19, 2023

It’s now time to get back to chemical probes and I’ll be taking a look at S2023 (Systematic literature review reveals suboptimal use of chemical probes in cell-based biomedical research) which has already been reviewed in blog posts from Practical Fragments , In The Pipeline and the Institute of Cancer Research.

Cell Based Assays

Cell Based Assays Research Compliance Laboratories

ChEMBL 34 is out!

The ChEMBL-og

APRIL 16, 2024

A company research code, or Clinical Trial intervention name, is assigned if no standardised name is available. For virtual parent compounds, progress has been made towards assigning a distinct pref_name (typically based on the FDA GSRS preferred name) that differs from the child compound name. University of Dundee: T.

Clinical Trials

Clinical Trials FDA Cell Based Assays Compound Screening

Pathogen data in ChEMBL

The ChEMBL-og

SEPTEMBER 1, 2021

In ChEMBL version 29, there are over 2 M bioactivity data points against fungal, bacterial or viral targets (for 460 K compounds) available for pathogen-related research. How can I find pathogen data? On the ChEMBL interface, the organism taxonomy is available as a filter that can be applied to bioactivity data.

Cell Based Assays

Cell Based Assays Screening Hits Small Molecule Virus

Atherosclerotic vascular disease | BMG LABTECH

BMG Labtech

OCTOBER 30, 2023

Microplate readers are useful tools for researchers to investigate the many facets of cardiovascular disease and provide different options for high-throughput research of atherosclerotic vascular disease. Researchers are interested in understanding the mechanisms of disease to facilitate possible interventions.

Disease

Disease Cell Based Assays Research Drugs

Araceli Biosciences Launches Endeavor High Content Analysis Platform

The Pharma Data

JANUARY 24, 2021

Endeavor revolutionizes drug discovery by delivering high speed, high resolution, full well scanning of cell-based assays. Endeavor images 10 times the biology in a fraction of the time, acquiring every cell, every time. We develop innovative products that accelerate basic research, drug discovery, and manufacturing.

Cell Based Assays

Cell Based Assays Laboratories Science Production

Use of Ultra-High-Throughput Screening in Discovery of COVID-19 Virus Structure

PerkinElmer

AUGUST 13, 2020

For this reason, researchers around the globe are scrambling to understand this novel virus and figure out its potentially targetable vulnerabilities. Speed is of critical importance to ongoing research efforts, given the virus’ rapid spread combined with a massive worldwide shortage of appropriate ventilator equipment.

Virus

Virus Cell Based Assays FDA Approval Clinical Trials

Measure Cell Metabolism with Microplate Readers | BMG LABTECH

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology

Molecular Biology Production Cell Based Assays Disease

Inside The Altascientist Issue 41: Immunomodulation Assessments for Clinical Trials–Sophisticated Bioanalytical Approaches to Support Complex Modalities

Alta Sciences

SEPTEMBER 27, 2024

For example, ELISA and multiplexed assays are used for quantifying proteins or cytokines, ELISpot is ideal for detecting antigen-specific T-cell responses, flow cytometry helps assess cell populations and functions, and cell-based assays are essential for evaluating the functional activity of immune cells.

Clinical Trials

Clinical Trials Trials Pharmacokinetics Small Molecule

Drug Discovery Digest

A covalent compound selectively inhibits RNA demethylase ALKBH5 rather than FTO

Machine learning’s growing importance in researching cells

Webinars

Trending Sources

New image-based cellular profiling tool peers deeply into metabolic biology

Webinars

Genetic variant identification: unveiling the power of STING-seq

Expanding Your Assay Specificity: Cisbio Joins PerkinElmer

Altasciences Completes Expansion of New State-Of-The-Art Laboratory in Columbia, Missouri

Accelerating Drug Discovery Through Repurposing

Assays for the Future of Drug Discovery

Separating the Hype from the Hyperbole Surrounding FDORA’s Alternatives to Animal Testing under the FD&C Act

tk

An industry leader’s perspective on the complexity of scientific data

AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

On quality criteria for covalent and degrader probes

Chemical con artists foil drug discovery

How are mRNA vaccines changing drug discovery?

Article FDA Thank You Draft guidance on potency assays for CGT products garners extensive stakeholder input

Exploring alternatives to animal testing in drug discovery

On the misuse of chemical probes

ChEMBL 34 is out!

Pathogen data in ChEMBL

Atherosclerotic vascular disease | BMG LABTECH

Araceli Biosciences Launches Endeavor High Content Analysis Platform

Use of Ultra-High-Throughput Screening in Discovery of COVID-19 Virus Structure

Measure Cell Metabolism with Microplate Readers | BMG LABTECH

Inside The Altascientist Issue 41: Immunomodulation Assessments for Clinical Trials–Sophisticated Bioanalytical Approaches to Support Complex Modalities

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