Cell Based Assays Research RNA 
Covalent Modifiers
FEBRUARY 25, 2024
Herein, we used a targeted covalent inhibition strategy and identified a covalent inhibitor, TD19, which selectively inhibits ALKBH5 compared with FTO demethylase in protein-based and tumor cell-based assays. TD19 irreversibly modifies the residues C100 and C267, preventing ALKBH5 from binding to m6A-containing RNA.
Broad Institute
JUNE 30, 2023
Previous Next To assess LipocyteProfiler, the researchers analyzed white and brown fat cells and liver cells, focusing on traits such as the size, the number, and the location of lipid droplets in a cell. Credit: Phil Kubitz, Claussnitzer lab A merged image showing all of the stained cellular components together.
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Tebu Bio: Drug Discovery
APRIL 24, 2020
Recombinant monoclonal antibody (mAB) based treatments have proven their efficacy. Nevertheless, researchers are now considering using messenger RNA (mRNA) technologies for the development of prophylactic and therapeutic vaccines. HIV or more recently SARS-Cov-2). Pre-clinical and clinical trials […]
Broad Institute
JUNE 21, 2023
Cell Painting uses six fluorescent dyes to image eight different components of a cell: the nucleus, nucleoli, mitochondria, endoplasmic reticulum (ER), golgi apparatus, cytoplasmic RNA, f-actin cytoskeleton, and plasma membrane. Typically, studying drug therapies is an expensive and time-consuming undertaking.
Elrig
APRIL 29, 2024
She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures. Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain.
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