Broad Institute

JUNE 30, 2023

Common genetic variants associated with cardiometabolic disease can produce phenotype changes of such small effect that they can be difficult to characterize. The researchers also looked at the tool’s ability to detect changes in cellular phenotypes after exposure to drugs and small molecule compounds.

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105

PerkinElmer

SEPTEMBER 8, 2019

Following the announcement that PerkinElmer has acquired Cisbio Bioassays , here is a little more information about the exciting opportunities this brings to life sciences researchers. The company notably developed a proprietary HTRF ® technology which is a type of TR-FRET assay used in Life Sciences. Learn more about Cisbio here.

Cell Based Assays 52

Cell Based Assays Small Molecule Science Pharmaceuticals 52

PerkinElmer

JANUARY 7, 2020

Successful researchers and companies master and use different technologies, making sure the interpretation of data does not suffer experimental or analytical bias and leads to better success rates and higher profitability for drug developers. In this assay, cells are incubated with the compound and heated.

Small Molecule 52

Small Molecule Cell Based Assays Drugs Drug Development 52

Broad Institute

JUNE 21, 2023

Common genetic variants associated with cardiometabolic disease can produce phenotype changes of such small effect that they can be difficult to characterize. The researchers also looked at the tool’s ability to detect changes in cell morphology after exposure to drugs and small molecule compounds.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

Molecular Design

DECEMBER 19, 2023

In any case, it needed to be made clear that the quality criteria proposed by the authors for covalently acting small-molecule probes only apply to probes that act irreversibly. Subscripting doesn't work well in blogger and so I'll use K.i As measurement of k.inact/K.i

Small Molecule 65

Small Molecule Biochemical Assays Cell Based Assays Drugs 65

Elrig

APRIL 29, 2024

Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain. Rising from Research Scientist to Senior Scientist, I supported early-stage DD efforts within their Protein Science group, based in Cambridge, UK.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Molecular Design

DECEMBER 31, 2023

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs 96

Drugs Packaging Cell Based Assays Small Molecule 96