PerkinElmer

JANUARY 7, 2020

There has been a resurgence of interest in the development of small molecules modulating kinases and of antibodies to cell surface receptors, guided by the selection of molecules having the longest residence time, as this is a key factor to the specificity and real efficacy of new therapeutics.

Small Molecule 52

Small Molecule Cell Based Assays Drugs Drug Development 52

Elrig

APRIL 29, 2024

My role involved generating and characterizing complex proteins critical for biological assay development, hit discovery, and structural biology. During this time, I had the opportunity to step in as an interim Discovery Sciences project lead, sparking my interest in project leadership.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Molecular Design

DECEMBER 31, 2023

The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.

Drugs 96

Drugs Packaging Cell Based Assays Small Molecule 96

The Premier Consulting Blog

APRIL 3, 2024

This guideline, which compliments the ICH Q2 2 Guideline, describes science and risk-based approaches for developing and maintaining analytical procedures suitable for the evaluation of the quality of drug substances and drug products.

Pharmaceuticals 52

Pharmaceuticals Cell Based Assays Production International 52

Molecular Design

SEPTEMBER 18, 2024

Different assay organism or cell types: the target protein may be recombinantly expressed in different cell types (the target ID in ChEMBL is assigned based on the original source of the target), or the assays may be run using different cell types.

Biochemical Assays 68

Biochemical Assays Drugs Biophysical Assays Cell Based Assays 68

Drug Target Review

JULY 6, 2023

allowing researchers to use “certain alternatives to animal testing, including cell-based assays and computer models, to obtain an exemption from the FDA to investigate the safety and effectiveness of a drug.” A new research paper, co-authored by PETA Science Consortium International e.V., Toxicological Sciences.

Animal Testing 105

Animal Testing Drugs Clinical Trials Clinical Research 105

The ChEMBL-og

APRIL 16, 2024

The data set of chemical probes was retrieved from 1) the chemicalprobes.org website and filtered for probes that were assigned an In Vivo Rating or In Cell Rating of 3 stars or more, and from 2) probes-drugs.org by filtering for the subsets “SGC Probes” and “Open Science Probes”. University of Dundee: T.

Clinical Trials 108

Clinical Trials FDA Cell Based Assays Compound Screening 108

The Pharma Data

JANUARY 24, 2021

Endeavor revolutionizes drug discovery by delivering high speed, high resolution, full well scanning of cell-based assays. Endeavor images 10 times the biology in a fraction of the time, acquiring every cell, every time. This press release features multimedia. View the full release here: [link].

Cell Based Assays 52

Cell Based Assays Laboratories Science Production 52

BMG Labtech

MARCH 8, 2023

In diagnostics, the increased glucose metabolism of cancer cells is used in positron emission tomography (PET) scans. Analysis of cell metabolism in life science research In biology, metabolic readouts can be used as key molecular indicators of healthy cellular functions or as predictors of disease (e.g., 101 (36): 13168–73.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

PerkinElmer

AUGUST 13, 2020

Following the high-throughput screening were cell-based assays, which demonstrated that the identified leads had strong anti-viral action. Of these 10,000 compounds, some were drugs already approved for other uses; others were drug candidates being used in clinical trials. Still others were simply known inhibitors of Mpro.

Virus 52

Virus Cell Based Assays FDA Approval Clinical Trials 52