Broad Institute
JUNE 30, 2023
The researchers also looked at the tool’s ability to detect changes in cellular phenotypes after exposure to drugs and small molecule compounds. With high-resolution, cell-based profiling techniques, extracting a large amount of data can be done cheaply and efficiently.
PerkinElmer
SEPTEMBER 8, 2019
The structure of HTRF reagents also makes assays highly resistant to most experimental conditions, and particularly well suited for cell-based assays. The post Expanding Your Assay Specificity: Cisbio Joins PerkinElmer first appeared on PerkinElmer Blog. Learn more about Cisbio here.
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PerkinElmer
JANUARY 7, 2020
Here are two predictions for the future: Alpha CETSA ® for target engagement While traditional assay methods detect either the displacement of a radioligand binding to the target by a competitor molecule, or the modulation of some function of the target, a new method is making headway: Cellular Thermo Shift Assay (CETSA) from Pelago Bioscience.
Molecular Design
DECEMBER 19, 2023
In any case, it needed to be made clear that the quality criteria proposed by the authors for covalently acting small-molecule probes only apply to probes that act irreversibly. Subscripting doesn't work well in blogger and so I'll use K.i As measurement of k.inact/K.i
Broad Institute
JUNE 21, 2023
The researchers also looked at the tool’s ability to detect changes in cell morphology after exposure to drugs and small molecule compounds. With high-resolution, cell-based profiling techniques, extracting large numbers of data can be done cheaply and efficiently.
Molecular Design
JUNE 8, 2023
Nevertheless, those small molecule drug properties that show consistent differentiation from their target compounds over time, namely, potency, ligand efficiencies (LE and LLE), and the aromatic ring count and lipophilicity of carboaromatic drugs, are those that are most likely to remain future-proof.
Molecular Design
DECEMBER 31, 2023
The effects of curcumin, EGCG (epigallocatechin gallate), genistein and resveratrol on four membrane proteins were reported in Ref9 and these effects would raise doubts about activity for any of these compounds (or their close structural analogs) that had been observed in a cell-based assay.
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