Alta Sciences

SEPTEMBER 27, 2024

The growing understanding of the immune system's role in various diseases, along with advancements in drug development, have led to a natural evolution from traditional vaccines, small molecules , and cytokines , to increased targeted biologics and innovative approaches in gene therapy and vaccines.

Clinical Trials 52

Clinical Trials Trials Pharmacokinetics Small Molecule 52

PerkinElmer

SEPTEMBER 8, 2019

The structure of HTRF reagents also makes assays highly resistant to most experimental conditions, and particularly well suited for cell-based assays. The post Expanding Your Assay Specificity: Cisbio Joins PerkinElmer first appeared on PerkinElmer Blog. Learn more about Cisbio here.

Cell Based Assays 52

Cell Based Assays Small Molecule Science Pharmaceuticals 52

Molecular Design

DECEMBER 19, 2023

In any case, it needed to be made clear that the quality criteria proposed by the authors for covalently acting small-molecule probes only apply to probes that act irreversibly. Subscripting doesn't work well in blogger and so I'll use K.i As measurement of k.inact/K.i

Small Molecule 69

Small Molecule Biochemical Assays Cell Based Assays Drugs 69

PerkinElmer

JANUARY 7, 2020

Here are two predictions for the future: Alpha CETSA ® for target engagement While traditional assay methods detect either the displacement of a radioligand binding to the target by a competitor molecule, or the modulation of some function of the target, a new method is making headway: Cellular Thermo Shift Assay (CETSA) from Pelago Bioscience.

Small Molecule 52

Small Molecule Cell Based Assays Drugs Drug Development 52

Molecular Design

JUNE 8, 2023

Nevertheless, those small molecule drug properties that show consistent differentiation from their target compounds over time, namely, potency, ligand efficiencies (LE and LLE), and the aromatic ring count and lipophilicity of carboaromatic drugs, are those that are most likely to remain future-proof.

Cell Based Assays 66

Cell Based Assays Small Molecule Drugs Clinical Development 66

Broad Institute

JUNE 21, 2023

The researchers also looked at the tool’s ability to detect changes in cell morphology after exposure to drugs and small molecule compounds. With high-resolution, cell-based profiling techniques, extracting large numbers of data can be done cheaply and efficiently.

Small Molecule 52

Small Molecule Cell Based Assays Medical Schools Disease 52

Broad Institute

JUNE 30, 2023

The researchers also looked at the tool’s ability to detect changes in cellular phenotypes after exposure to drugs and small molecule compounds. With high-resolution, cell-based profiling techniques, extracting a large amount of data can be done cheaply and efficiently.

Small Molecule 105

Small Molecule Cell Based Assays Disease Assay Development 105