Chemical Biology and Drug Design

JULY 26, 2023

lncRNA, miRNA, siRNA, receptors, and proteins) are added to exosomes which are released from the parental cells. Abstract Noncoding RNAs (ncRNAs) are engaged in key cell biological and pathological events, and their expression alteration is connected to cancer progression both directly and indirectly.

Engineering 100

Engineering Therapies Cell Biology Drugs 100

Drug Target Review

JULY 13, 2023

The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

Chemical Biology and Drug Design

JANUARY 5, 2024

After the corresponding transfection or treatment with inhibitor of catenin-responsive transcription-3 (iCRT-3), abovementioned CRC cell biological behaviors as well as expression levels of HOXB7 and β-catenin were evaluated. μM THA dwindled CRC cell viability, migration, and invasion, and facilitated apoptosis.

Bioinformatics 100

Bioinformatics Cell Biology Treatment Research 100

Chemical Biology and Drug Design

JULY 27, 2023

DDP-resistant NPC cells were established by treatment with DDP at increased concentrations (2, 4, 6, 8, or 10 μg/mL). Cell biological behaviors were assessed via cell function experiments. MicroRNA-577 and EIF5A2 mRNA expressions were detected by qRT-PCR.

Cell Biology 100

Cell Biology Regulations Treatment Research 100

KIF1A

MARCH 2, 2024

Read the Article Rare Roundup The Jackson Laboratory offers “Exploring Rare Disease Through Translational Research” MiniCourse Human health is incredibly complex; developing safe, effective treatments requires knowledge of molecular mechanisms, cell biology, and drug administration.

Laboratories 119

Laboratories Cell Biology Disease Research 119

Broad Institute

DECEMBER 13, 2023

Hacohen Group, Cell Circuits Bhaavana Oruganty Swarthmore College Engineering (major), B.S., Chemistry (minor) Golub Lab, Cancer Program Ava Perry Texas A&M University Molecular and Cell Biology (major), B.S., Biochemistry (minor) Golub Lab, Cancer Program Alexander Rojas Emory University Biology B.S.

Molecular Biology 52

Molecular Biology Cell Biology Science Engineering 52

Drug Target Review

NOVEMBER 17, 2023

Professor Alan Trounson AO CEO, Executive Director, Cartherics Alan is the past President of the Californian Institute for Regenerative Medicine (2007-2014), the Californian state’s $3 billion stem cell agency driving research in stem cell biology and facilitating the translation of stem cell discoveries into clinical therapies.

Therapies 118

Therapies Cell Biology Clinical Trials Trials 118

Broad Institute

FEBRUARY 29, 2024

Prior to joining the platform, Lipinski worked for almost five years as a postdoc with Paola Arlotta at Harvard Department of Stem Cell and Regenerative Biology and Stanley Center for Psychiatric Research. There, he used cortical organoid models of bipolar disorder to study patient response to lithium. Lipinski earned his Ph.D.

Cell Biology 52

Cell Biology Disease Science Research 52

The Pharma Data

OCTOBER 27, 2021

million expansion will bring high quality seeds to worldwide markets faster, providing solutions for growers and meeting consumer demands / The seven-hectare global Product Design Center in San Nicolás includes state-of-the-art lab space for cell biology research and greenhouses for seed production.

Cell Biology 40

Cell Biology Production Laboratories Marketing 40

Drug Target Review

OCTOBER 16, 2023

Nikki drives adoption of 3D cellular models of human disease by applying her expertise in cell biology to drug discovery and high-throughput screening. About the author Nikki Carter Commercial Organoid Innovation Director, Molecular Devices. Nikki’s life sciences experience spans leadership, commercial and research roles.

Disease 122

Disease Immune Response Cell Biology Therapies 122

The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g.

Cell Biology 52

Cell Biology Molecular Biology Science Research 52

Drug Target Review

NOVEMBER 24, 2023

Achieving a mouse brain map has been made possible by advances in computing and data processing, as well as previous work by Lichtman and other researchers like Professor Florian Engert in molecular and cell biology, studying the brains of fruit flies and zebrafish.

Cell Biology 105

Cell Biology Engineering Research Treatment 105

Drug Target Review

AUGUST 10, 2023

When bound to GRP78, ID2 loses its inhibitory function, leading to increased invasiveness of cancer cells. Implications for cancer therapeutics and beyond These findings have wide-ranging implications for cancer treatment and cell biology research.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

Drug Target Review

JUNE 5, 2023

Prior to joining Zymeworks, Paul served as Vice President, Cell Biology, and Immunology at MacroGenics, where he worked on the development of numerous clinical stage compounds and scientific collaborations with a range of pharmaceutical partners.

Treatment 100

Treatment Pharmacokinetics Drugs Cell Biology 100

Drug Target Review

APRIL 12, 2024

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. He is the CEO and cofounder of SEED Biosciences Ltd, a spinoff from the EPFL.

Cell Biology 105

Cell Biology FDA Approval FDA Research 105

Drug Target Review

APRIL 12, 2024

With its disruptive pipetting technology, SEED Biosciences is bridging the gap between the capabilities in liquid handling and the opportunities in single cell biology. He is the CEO and cofounder of SEED Biosciences Ltd , a spinoff from the EPFL.

Cell Biology 98

Cell Biology FDA Approval FDA Research 98

PerkinElmer

JANUARY 21, 2022

Accelerating Capabilities for Dementia Biomarker Discovery To achieve that goal, the Dementia Platform’s focus involves studying the disease from many points of view – from lifestyle, age, and cognitive function, to genetics, cell biology, and phenotypic screening.

Cell Biology 52

Cell Biology Disease Treatment Science 52

Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

The Pharma Data

SEPTEMBER 21, 2020

The funding will be used to develop a pipeline of ‘highly selective’ gene therapies targeting cancer stem cells in a variety of solid tumour types. It will draw on research led by Professor Steven Pollard at the University of Edinburgh, which delved into stem cell biology, synthetic biology and cancer genomics.

Therapies 52

Therapies Cell Biology Licensing Licensing 52

Drug Target Review

APRIL 9, 2024

Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects. In 2005, he joined CNIO to lead the Genomic Instability Group where he has been ever since.

RNA 64

RNA Cell Biology Clinical Development DNA 64

Drug Target Review

JUNE 7, 2024

She has deep knowledge in Immunology and T cell biology, and 13 years of experience in Research (seven of them in biotech at Immunocore), including pipeline programme leadership. Dr Ribeiro holds a PhD in Biomedical Sciences from University of Porto, Portugal, studying T cell and thymus development.

Engineering 81

Engineering Clinical Trials Therapies Cell Biology 81

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. When I began my PhD I completely switched my focus, and I haven’t looked back,” said Manguso.

Research 137

Research Immune Response Clinical Trials Therapies 137

The Pharma Data

FEBRUARY 24, 2022

Their findings are published online in Nature Cell Biology. “We are amazed by the efficiency of small-molecule PROTAC in simultaneously targeting EZH2 and cMyc in cancer cells.” MS177 targets both EZH2 and cMyc and thus inhibit cancer growth.

Small Molecule 52

Small Molecule Cell Biology Research Drug Development 52

The Pharma Data

JUNE 26, 2021

Wolff Distinguished Professor of Cell Biology & Physiology, planned to study the molecular changes that occur inside cells infected with SARS-CoV-2. This is something we definitely need to know more about.” ” The finding was serendipitous. Last year, Kutluay and co-senior author M. Ben Major, PhD, the Alan A.

Virus 52

Virus Cell Biology Vaccine Research 52

Reprocell

NOVEMBER 20, 2023

CHIR99021, also known as CT99021, is a small molecule compound that has proven to be a potent and versatile tool in the world of stem cell biology and regenerative medicine. It acts as a selective inhibitor of glycogen synthase kinase 3 (GSK-3) with a high affinity for GSK-3β.

Research 52

Research Small Molecule Cell Biology 52

Drug Target Review

NOVEMBER 1, 2023

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. Umezu-Goto M, Kishi Y, Taira A, et al. 2002 Jul 22;158(2):227–33. Valdés-Rives SA, González-Arenas A. Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development.

Clinical Trials 134

Clinical Trials Small Molecule Trials Disease 134

Broad Institute

MARCH 25, 2024

in cell biology. Navarro later became the first in her family to attend a four-year college, earning her degree in microbiology from the University of Texas at El Paso, followed by a stint doing research at Novartis in Cambridge, MA, and then graduate studies at MIT to earn her Ph.D.

Science 111

Science Cell Biology Research DNA 111

The Pharma Data

MARCH 25, 2022

. “With the help of advanced laboratory techniques, we were able to identify a panel of nanobodies that very effectively neutralized several variants of SARS-CoV-2,” says Gerald McInerney, professor at the Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, and joint senior author of both studies.

Molecular Biology 52

Molecular Biology Laboratories Cell Biology Science 52

The Pharma Data

JUNE 28, 2021

. • Addie Thompson – Michigan State University • Ana Laura Torres Huerta – Monterey Institute of Technology • Bryan Berger – University of Virginia • Eduardo Rodriguez – Institute of Molecular and Cell Biology of Rosario • Elizabeth Skellam – University of North Texas • Enrico Bonello – Ohio State University • Haoyu Niu – University of California, (..)

Research 52

Research Cell Biology Science Disease 52

Drug Target Review

OCTOBER 2, 2024

Continued growth in the field relies on multidisciplinary efforts combining biology, engineering, and clinical medicine. Ongoing innovation in stem cell biology, gene editing, delivery technologies, and advanced biomaterials is likely to address many of the current obstacles.

Therapies 98

Therapies Disease Engineering RNA 98

The Pharma Data

MARCH 15, 2022

. “The problem is that cells only make small amounts of p53 and then quickly break it down as it is a very large and disordered protein,” says the study’s last author Michael Landreh, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet.

Cell Biology 52

Cell Biology DNA Research Vaccine 52

Broad Institute

NOVEMBER 2, 2023

We've been using those for a long while, for modeling various aspects of biology like genomic variation, experimental artifacts, single-cell biology, and other areas. Generative AI is something that has been brewing for a long time in the machine learning community, going back to the fundamental tenets of Bayesian statistics.

Research 124

Research Engineering Science Cell Biology 124

Drug Target Review

JANUARY 30, 2024

About the author Dr Jia-Jia Zhang, Doctoral candidate Dr Jia-Jia Zhang is a doctoral candidate at the National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, and her research interest is the development of therapeutical antibodies to treat human disease.

Treatment 52

Treatment Doctors Cell Biology Regulations 52

The Pharma Data

DECEMBER 1, 2020

Innate has been a pioneer in the understanding of natural killer cell biology and has expanded its expertise in the tumor microenvironment and tumor-antigens, as well as antibody engineering.

Cell Biology 52

Cell Biology Clinical Trials Production Licensing 52

Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. I carried that appetite for knowledge, coupled with a driven work ethic, through my graduate and post-graduate studies at the University College London.

Small Molecule 115

Small Molecule Targeted Protein Degradation Science Disease 115

Drug Target Review

AUGUST 24, 2023

Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology. Biophysical Journal. 2021 Jul 6;120(13):2644-56. Springer TA, Dustin ML. Integrin inside-out signaling and the immunological synapse. 2012 Feb 1;24(1):107-15.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

Drug Target Review

JANUARY 31, 2024

Sara holds a bachelor’s degree in Pharmaceutical Sciences and a PhD in Pharmacology and Toxicology from the University of California, Irvine and completed her post-doctoral fellowship training in cardiovascular cell biology from the Lerner Research Institute at the Cleveland Clinic in Ohio.

Clinical Trials 97

Clinical Trials Production Science Research 97