Drug Target Review

NOVEMBER 17, 2023

They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells). NK cells can be readily extracted from umbilical cord blood or peripheral blood of adult donors.

Therapies 118

Therapies Clinical Trials Cell Biology Trials 118

Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. TPD engages the body’s natural protein recycling system by selectively eliminating disease-causing proteins, ultimately addressing the root cause of disease.

Small Molecule 116

Small Molecule Targeted Protein Degradation Science Disease 116

Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

Drug Target Review

DECEMBER 21, 2023

Dr Susanne Rafelski, who led the study, spoke with Drug Target Review about how the study was conducted, how it might apply to diseases and future directions. SR: This project started in the early days of the Allen Institute for Cell Science, nearly seven years ago. In disease, what goes wrong in cells can often be seen by eye.

International 105

International Science Disease Research 105

KIF1A

MAY 24, 2023

In this blog post, KIF1A.ORG Chief Science Officer Dr. Dominique Lessard describes a unique cross disciplinary experience with multiple scientific stakeholders in the rare disease space, all focused around our holistic understanding of KAND. How do we move the needle to make patient voices and experiences the center of scientific discovery?

Disease 98

Disease Laboratories Research Science 98

Broad Institute

DECEMBER 13, 2023

Hung Group, Infectious Disease and Microbiome Program Michael Bogaev Princeton University Molecular Biology (major), B.A., Spanish (minor) Genetic Pertubation Platform (GPP) Mohammed Mutaher Harvard University Human Developmental and Regenerative Biology (major), B.A.,

Molecular Biology 52

Molecular Biology Cell Biology Science Engineering 52

Drug Target Review

JUNE 7, 2024

Built on our proprietary ImmTAX (Immune Mobilizing Monoclonal TCRs Against X disease) platform, Immunocore has a diverse portfolio of bispecific therapies across three disease areas (cancer, infectious and autoimmune diseases).

Engineering 81

Engineering Clinical Trials Therapies Cell Biology 81

Drug Target Review

SEPTEMBER 19, 2023

This model recapitulates tissue-tissue interface, vascular perfusion with circulating immune cells, connective tissue cells and organ-relevant mechanical flow dynamics. From 3D cell culture to organs-on-chips. Trends in Cell Biology. References Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE.

Animal Testing 98

Animal Testing Clinical Trials Pharmaceutical Companies FDA 98

Broad Institute

NOVEMBER 2, 2023

He talked about how generative AI techniques can be used not just to analyze human language but also the language of genes and cells — raw biological data — to shed light on how cells and tissues work in health and disease. Can generative AI be useful for hypothesis generation?

Research 124

Research Engineering Science Cell Biology 124

Broad Institute

FEBRUARY 29, 2024

He joined the platform in December 2023 and his interest lies in using spatial transcriptomics sequencing methods to study psychiatric disease. He hopes to model and investigate drug responses in diseased neuronal systems, ultimately aiming to improve mental health treatments that have stalled in recent decades.

Cell Biology 52

Cell Biology Disease Science Treatment 52

Drug Target Review

APRIL 9, 2024

How has nucleolar stress (NS) been linked to age-related diseases, and what approach did researchers use to investigate its toxicity? The nucleolus (and nucleolar stress) had been previously linked to aging and age-related diseases such as cancer or degeneration.

RNA 64

RNA Cell Biology Clinical Development Disease 64

DrugBank

JUNE 27, 2023

Out of the millions of genetic variants present in human populations, GWAS are designed to uncover those associated with specific traits or diseases. 9 Polygenic diseases are much more common, and thousands of genetic variants with very small effects could impact their phenotype.

Disease 98

Disease Treatment Drugs Clinical Trials 98

Broad Institute

MARCH 25, 2024

in cell biology. During college, I studied microbiology and developed an interest in infectious disease. In my honors biology class, I chatted with my professor about a report I wrote on cancer therapeutics. It was the first scientific conversation I had in which someone asked me, “What do you think about this?

Science 111

Science Cell Biology Research DNA 111

Drug Target Review

AUGUST 10, 2023

Published in the Proceedings of the National Academy of Sciences , a new discovery from the University of Southern California (USC) on cancer metastasis has opened up new possibilities for combating the spread of this devastating disease.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

The Pharma Data

OCTOBER 27, 2021

million expansion will bring high quality seeds to worldwide markets faster, providing solutions for growers and meeting consumer demands / The seven-hectare global Product Design Center in San Nicolás includes state-of-the-art lab space for cell biology research and greenhouses for seed production.

Cell Biology 40

Cell Biology Production Laboratories Marketing 40

Drug Target Review

JANUARY 31, 2024

Early in my education, I developed an interest in understanding how chemical entities derived from natural resources could be modified and used to fight specific diseases.

Clinical Trials 97

Clinical Trials Production Science Research 97

Drug Target Review

AUGUST 24, 2023

These findings were mirrored in the clinical results from an analysis of two metastatic melanoma patient cohorts who received anti-PD-1 treatment: patients with responses and disease control had significantly lower GDF-15 serum levels (measured before treatment start), while none of the patients with elevated GDF-15 levels showed a lasting response.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

The Pharma Data

JUNE 28, 2021

Proposals like Kavamura’s, on fighting fungal disease in wheat with microbes, centered around solutions aimed at helping farmers around the world protect their crops. Bayer offers a lot of support from its experienced team, and I hope I have some exciting results which could lead to additional future collaborations”.

Research 52

Research Cell Biology Science Disease 52

Drug Target Review

MAY 22, 2023

Dr Susanne Rafelski, who led the study, spoke with Drug Target Review about how the study was conducted, how it might apply to diseases, and future directions. This project started in the early days of the Allen Institute for Cell Science, nearly seven years ago. In disease, what goes wrong in cells can often be seen by eye.

International 59

International Science Disease Research 59

BMG Labtech

MARCH 9, 2023

Mitochondrial toxicity can occur when drugs or diseases affect the mitochondria and prevent the proper production of energy. Read, how to measure it with plate readers.

Disease 52

Disease Production Drugs Cell Biology 52

The Pharma Data

JANUARY 3, 2021

“I look forward to working with Scott and his team at NexImmune to help advance and expand the Company’s research and development pipeline with the ultimate goal of developing next-generation immunotherapies for patients suffering from immune-mediated conditions related to cancers and autoimmune/inflammatory diseases,” Dr. Zeldis commented. “It

Immune Response 40

Immune Response Clinical Trials Therapies Cell Biology 40

Elrig

APRIL 29, 2024

Jasmine has a background in neuroscience and genetic manipulation, with early works focused on using a combined structural and molecular biology approach to assess disease-associated proteins implicated in Alzheimer’s disease.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Drug Target Review

JANUARY 30, 2024

About the author Dr Jia-Jia Zhang, Doctoral candidate Dr Jia-Jia Zhang is a doctoral candidate at the National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, and her research interest is the development of therapeutical antibodies to treat human disease.

Treatment 52

Treatment Doctors Cell Biology Regulations 52

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

Links: High Resolution Electron Microscopy (National Cancer Institute/NIH) Xu Laboratory (Van Andel Research Institute, Grand Rapids, MI) Kossiakiff Lab (University of Chicago) Transformative High Resolution Cryo-Electron Microscopy Program (NIH Common Fund) NIH Support: National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer (..)

Laboratories 52

Laboratories Research Regulations Drugs 52

New Drug Approvals

JANUARY 9, 2024

The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. Recent genetic and biochemical studies have confirmed the importance of CDK7 for cell cycle progression (Larochelle.

Production 62

Production DNA RNA Regulations 62

Drug Target Review

JUNE 5, 2023

Differentiated treatment options are needed, as cancer is a diverse disease that varies across and within organs due to many factors such as genetics, epigenetic influence as well as treatments (lines & type therapy). No single therapeutic mode has cured all cancers, so diversification in research and treatment is warranted.

Treatment 100

Treatment Pharmacokinetics Drugs Cell Biology 100

Drug Target Review

OCTOBER 2, 2024

Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. Early-phase clinical trials have shown the safety and efficacy of using stem cells for cardiac repair, encouraging further research and development.

Therapies 98

Therapies Disease Engineering RNA 98

Codon

APRIL 9, 2024

“Cumulatively the deadliest of the human infectious diseases,” malaria has been documented throughout recorded history. In this light, scouring old Chinese remedies for new treatments for a disease specifically troublesome during war was entirely intuitive for Chinese biomedical scientists like Tu Youyou in the mid-20th century.

Drugs 140

Drugs Science Research Doctors 140

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. His mother had a presentation of the disease that suggested her immune system was already on the job.

Research 137

Research Immune Response Clinical Trials Therapies 137

PerkinElmer

JANUARY 21, 2022

Dementias include a wide spectrum of neurodegenerative disorders, including Parkinson’s disease, Motor Neuron diseases, Multiple Sclerosis, Huntington’s disease, Creutzfeldt–Jakob disease, and Alzheimer’s disease. That’s right, the MRC says. To achieve that, Prof. 2022 [cited 6 January 2022].

Cell Biology 52

Cell Biology Disease Treatment Science 52

The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g.

Cell Biology 52

Cell Biology Molecular Biology Science Research 52

Drug Target Review

DECEMBER 21, 2023

And really, this comes to the biggest question of all: what is the underlying mechanism of a given disease? There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype. And this is exactly where AI can provide us with an extremely powerful new strategy.

Disease 105

Disease Small Molecule Vaccine Drugs 105

Drug Target Review

JUNE 29, 2023

Because we are using cells as medicines, they’re living medicines that we hope that they become cancer treatments where it’s literally one dose and you’re done. When it comes down to cell biology itself, cells can do so many different things.

Therapies 115

Therapies Science Production Cell Biology 115

The Pharma Data

OCTOBER 19, 2020

an emerging leader focused on the treatment of kidney disease, sepsis and organ injury, today announced the appointment of Maarten Kraan, M.D., in Cell Biology from Utrecht University. AM-Pharma’s purpose is to save and improve the lives of patients confronted with kidney disease, sepsis and organ injury.

Trials 40

Trials Small Molecule Cell Biology Clinical Trials 40

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind are probably viruses and bacteria. Caption: Cyclic peptide (middle) binds to iPGM (blue). But parasites are another important source of devastating infection, especially in the developing world.

Small Molecule 52

Small Molecule Science Drug Development Disease 52

Precision for Medicine

APRIL 7, 2023

Our new state-of-the-art laboratory, combined with the deep knowledge of our scientists, gives an advantage to clients developing novel therapeutics and diagnostic products in oncology, liver disease, and skin diseases. Senior Vice President at Precision for Medicine.

Laboratories 52

Laboratories Clinical Research Clinical Trials Cell Biology 52