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How nucleolar stress accelerates aging in mice

Drug Target Review

How has nucleolar stress (NS) been linked to age-related diseases, and what approach did researchers use to investigate its toxicity? The nucleolus (and nucleolar stress) had been previously linked to aging and age-related diseases such as cancer or degeneration.

RNA 64
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#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers

Broad Institute

in cell biology. During college, I studied microbiology and developed an interest in infectious disease. In my honors biology class, I chatted with my professor about a report I wrote on cancer therapeutics. Each cell needs the same amount of DNA so they can function like each other.

Science 111
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Precision Medicine in the Genomic Era

DrugBank

Out of the millions of genetic variants present in human populations, GWAS are designed to uncover those associated with specific traits or diseases. 9 Polygenic diseases are much more common, and thousands of genetic variants with very small effects could impact their phenotype.

Disease 98
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AI At The Frontier: Empowering Early Career Professionals In Drug Discovery

Elrig

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing.

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TACACICLIB, AUR-102, AURIGENE

New Drug Approvals

The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. Recent genetic and biochemical studies have confirmed the importance of CDK7 for cell cycle progression (Larochelle. Cancer Res.

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Cell and gene therapy development moves into cardiac indications

Drug Target Review

Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. Early-phase clinical trials have shown the safety and efficacy of using stem cells for cardiac repair, encouraging further research and development.

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A research team searches for every gene that helps tumors evade immunotherapy

Broad Institute

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. His mother had a presentation of the disease that suggested her immune system was already on the job.

Research 137