DrugBank

JUNE 27, 2023

The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care.

Disease 98

Disease Treatment Drugs Clinical Trials 98

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind are probably viruses and bacteria. But parasites are another important source of devastating infection, especially in the developing world. Nat Commun. 2017 Apr 3;8:14932.

Small Molecule 52

Small Molecule Science Drug Development Disease 52

Elrig

APRIL 29, 2024

Jasmine has a background in neuroscience and genetic manipulation, with early works focused on using a combined structural and molecular biology approach to assess disease-associated proteins implicated in Alzheimer’s disease.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

Links: High Resolution Electron Microscopy (National Cancer Institute/NIH) Xu Laboratory (Van Andel Research Institute, Grand Rapids, MI) Kossiakiff Lab (University of Chicago) Transformative High Resolution Cryo-Electron Microscopy Program (NIH Common Fund) NIH Support: National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer (..)

Laboratories 52

Laboratories Research Drugs Regulations 52

New Drug Approvals

JANUARY 9, 2024

The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. Recent genetic and biochemical studies have confirmed the importance of CDK7 for cell cycle progression (Larochelle.

Production 62

Production DNA RNA Regulations 62

Codon

APRIL 9, 2024

“Cumulatively the deadliest of the human infectious diseases,” malaria has been documented throughout recorded history. In this light, scouring old Chinese remedies for new treatments for a disease specifically troublesome during war was entirely intuitive for Chinese biomedical scientists like Tu Youyou in the mid-20th century.

Drugs 137

Drugs Science Research Doctors 137

Drug Target Review

APRIL 1, 2025

Advances in biotechnology are driving significant progress in the treatment of rare diseases, making it possible to develop targeted therapies for previously untreatable conditions. Founded in 2021, SynaptixBio is working to develop therapies for TUBB4A leukodystrophies – a group of rare and severe neurological disorders.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Broad Institute

NOVEMBER 21, 2024

Bernstein is also chair of the Department of Cancer Biology at Dana-Farber Cancer Institute, a professor in cell biology and pathology at Harvard Medical School, and holds the Richard and Nancy Lubin Family Chair. Inevitable progression Gliomas arise from glial cells, which protect and support a healthy nervous system.

Research 124

Research Medical Schools DNA Hospitals 124

Drug Target Review

JANUARY 16, 2025

These sites are commonly involved in protein-protein interactions, some of which are key to disease development. Food and Drug Administration (FDA) approved drugs, macrocycles are used to combat a range of diseases, including cancer, viral, fungal and bacterial infections, neurodegenerative and autoimmune diseases.

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52