Drug Target Review

JULY 13, 2023

Dewpoint Therapeutics, a platform drug discovery company founded in 2018, has been at the forefront of this exciting field. Dr Isaac Klein, Chief Scientific Officer at Dewpoint, brings a wealth of knowledge and expertise to the field of drug discovery. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98

Disease Small Molecule Cell Biology Drugs 98

KIF1A

MARCH 2, 2024

#ScienceSaturday posts share exciting scientific developments and educational resources with the KAND community. Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. Want to learn more about translational research?

Laboratories 119

Laboratories Cell Biology Disease Research 119

Drug Target Review

APRIL 9, 2024

How has nucleolar stress (NS) been linked to age-related diseases, and what approach did researchers use to investigate its toxicity? The nucleolus (and nucleolar stress) had been previously linked to aging and age-related diseases such as cancer or degeneration.

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RNA Cell Biology Clinical Development DNA 64

Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind are probably viruses and bacteria. But parasites are another important source of devastating infection, especially in the developing world. Nat Commun. 2017 Apr 3;8:14932.

Small Molecule 52

Small Molecule Science Drug Development Disease 52

Drug Target Review

SEPTEMBER 19, 2023

This model recapitulates tissue-tissue interface, vascular perfusion with circulating immune cells, connective tissue cells and organ-relevant mechanical flow dynamics. 3-5 Boston biotech, Emulate, established liver-on-chip device is designed to accurately measure liver toxicity and predict drug induced liver injury (DILI).

Animal Testing 98

Animal Testing Clinical Trials Pharmaceutical Companies FDA 98

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

Links: High Resolution Electron Microscopy (National Cancer Institute/NIH) Xu Laboratory (Van Andel Research Institute, Grand Rapids, MI) Kossiakiff Lab (University of Chicago) Transformative High Resolution Cryo-Electron Microscopy Program (NIH Common Fund) NIH Support: National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer (..)

Laboratories 52

Laboratories Research Regulations Drugs 52