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We wanted to build a tool like that for cellbiology. So we took lots of reference single-cellRNA sequencing data from atlases and used our scalable machine learning algorithms to embed all of the gene expression data on these cells into compact vector representations — you can think of these as a signature for each cell.
Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. Early-phase clinical trials have shown the safety and efficacy of using stem cells for cardiac repair, encouraging further research and development.
Shortly after finishing my studies, I landed my first job in industry working on cellbiology research for several disease indications. TPD engages the body’s natural protein recycling system by selectively eliminating disease-causing proteins, ultimately addressing the root cause of disease.
How has nucleolar stress (NS) been linked to age-related diseases, and what approach did researchers use to investigate its toxicity? The nucleolus (and nucleolar stress) had been previously linked to aging and age-related diseases such as cancer or degeneration. However, the mechanism of this observation was not fully understood.
By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cellbiology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. His mother had a presentation of the disease that suggested her immune system was already on the job.
Published in the Proceedings of the National Academy of Sciences , a new discovery from the University of Southern California (USC) on cancer metastasis has opened up new possibilities for combating the spread of this devastating disease.
These findings were mirrored in the clinical results from an analysis of two metastatic melanoma patient cohorts who received anti-PD-1 treatment: patients with responses and disease control had significantly lower GDF-15 serum levels (measured before treatment start), while none of the patients with elevated GDF-15 levels showed a lasting response.
Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. Nature Chemical Biology. Current Biology.
She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures. Harini joined Serna Bio in early 2021 and has been an integral part of the multidisciplinary teamworking on target ID platform development to drug discovery.
Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). By combining this new variant with standard sequencing methods, it’s possible to identify RNA modifications in a really simple way. Communications Biology. Cell Systems.
If these printers were set up in resource-starved countries, where malaria and other diseases are endemic, they could make a world of difference. 5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. Nature CellBiology. Synthetic Biology.
If these printers were set up in resource-starved countries, where malaria and other diseases are endemic, they could make a world of difference. 5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. Nature CellBiology. Synthetic Biology.
The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. Recent genetic and biochemical studies have confirmed the importance of CDK7 for cell cycle progression (Larochelle.
They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days.
Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature CellBiology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Nature Biotechnology.
Nature Reviews Molecular CellBiology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular CellBiology (2014). . & Weiss R.
Nature Reviews Molecular CellBiology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular CellBiology (2014). . & Weiss R.
Amodei also imagines the ways AI could accelerate biological research and yield miraculous cures in the 21st century; everything from the prevention and treatment of nearly all infectious and inherited diseases to the elimination of most cancers. This essay focuses on how we might do both, specifically for the cell. Even the humble E.
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