Drug Target Review

DECEMBER 21, 2023

A recently published study 1 from a large team of cell biologists sheds new light on cellular organisation and variability. Dr Susanne Rafelski, who led the study, spoke with Drug Target Review about how the study was conducted, how it might apply to diseases and future directions. Cancer pathology is a clear example of that.

International 105

International Science Disease Research 105

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. His mother had a presentation of the disease that suggested her immune system was already on the job.

Research 137

Research Immune Response Clinical Trials Therapies 137

Drug Target Review

OCTOBER 31, 2023

I always knew I wanted to study biology. My interest in science started in grade school, then continued through high school and finally into college. I was sure that Biology would be my major, but it required studying maths, and this was my first obstacle. Understanding the connection between STEM subjects is critical.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

Drug Target Review

SEPTEMBER 19, 2023

This model recapitulates tissue-tissue interface, vascular perfusion with circulating immune cells, connective tissue cells and organ-relevant mechanical flow dynamics. Closing remarks Solution based science, but not problem-based science becomes the basis of success of science. 2010;328(5986):1662-8.

Animal Testing 98

Animal Testing Clinical Trials Pharmaceutical Companies FDA 98

Broad Institute

NOVEMBER 2, 2023

By Corie Lok November 2, 2023 Credit: Maria Nemchuk, Broad Communications Mehrtash Babadi is director of computational methods in Broad's Data Sciences Platform The recent explosion of generative AI tools has prompted many discussions in virtually all fields about the benefits and risks of these technologies.

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Research Engineering Science Cell Biology 124

KIF1A

MAY 24, 2023

In this blog post, KIF1A.ORG Chief Science Officer Dr. Dominique Lessard describes a unique cross disciplinary experience with multiple scientific stakeholders in the rare disease space, all focused around our holistic understanding of KAND. A lot more than you’d think! Finally, like humans, C. elegans neurons”.

Disease 98

Disease Laboratories Research Science 98

Broad Institute

MARCH 25, 2024

By Leah Eisenstadt March 25, 2024 Credit: Allison Colorado, Broad Communications Alex Navarro, Senior Program Coordinator for the Broad Biomedical Post-baccalaureate Scholars Program Alex Navarro didn’t always aspire to a career in science. in cell biology. It was fun to spend so much time watching cells divide.

Science 111

Science Cell Biology Research DNA 111

Broad Institute

DECEMBER 13, 2023

Hung Group, Infectious Disease and Microbiome Program Michael Bogaev Princeton University Molecular Biology (major), B.A., Neuroscience (minor) Lander Lab Nina Gonzalez Bates University Biological Sciences (major), B.A., Hacohen Group, Cell Circuits Bhaavana Oruganty Swarthmore College Engineering (major), B.S.,

Molecular Biology 52

Molecular Biology Cell Biology Science Engineering 52

The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Early Excellence in Science Awards 2020.

Cell Biology 52

Cell Biology Molecular Biology Science Laboratories 52

Drug Target Review

JUNE 7, 2024

Built on our proprietary ImmTAX (Immune Mobilizing Monoclonal TCRs Against X disease) platform, Immunocore has a diverse portfolio of bispecific therapies across three disease areas (cancer, infectious and autoimmune diseases).

Engineering 81

Engineering Clinical Trials Therapies Cell Biology 81

PerkinElmer

JANUARY 21, 2022

1 To address the urgent need for new therapies, the UK’s Medical Research Council (MRC), a national public agency supporting health science and research, established the Dementias Platform United Kingdom (DPUK) in 2014. Unless something is done, experts predict these numbers will likely double within the next 20 years. To achieve that, Prof.

Cell Biology 52

Cell Biology Disease Treatment Science 52

Broad Institute

FEBRUARY 29, 2024

He joined the platform in December 2023 and his interest lies in using spatial transcriptomics sequencing methods to study psychiatric disease. He hopes to model and investigate drug responses in diseased neuronal systems, ultimately aiming to improve mental health treatments that have stalled in recent decades. He also holds a B.Sc.

Cell Biology 52

Cell Biology Disease Science Treatment 52

Drug Target Review

JANUARY 31, 2024

As a female undergraduate student studying pharmaceutical sciences, one of the biggest challenges was not having enough female leaders as mentors. Early in my education, I developed an interest in understanding how chemical entities derived from natural resources could be modified and used to fight specific diseases.

Clinical Trials 97

Clinical Trials Production Science Research 97

Precision for Medicine

APRIL 7, 2023

The custom-designed laboratory accommodates the growth in demand for advanced digital pathology and imaging capabilities, expertise in molecular sciences and a wide array of sequencing technologies. “Our This convergence of trials, labs, and data sciences is driving faster clinical development and approval.

Laboratories 52

Laboratories Clinical Research Clinical Trials Cell Biology 52

Drug Target Review

MAY 22, 2023

A recently published study 1 from a large team of cell biologists sheds new light on cellular organisation and variability. Dr Susanne Rafelski, who led the study, spoke with Drug Target Review about how the study was conducted, how it might apply to diseases, and future directions. Cancer pathology is a clear example of that.

International 59

International Science Disease Research 59

Drug Target Review

JUNE 29, 2023

Can you tell us about your journey in the field of science, technology, engineering and maths (STEM) and the challenges you encountered along the way? At school I was encouraged to follow science because I was good at it. When it comes down to cell biology itself, cells can do so many different things.

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Therapies Science Production Cell Biology 115

The Pharma Data

JUNE 28, 2021

24 scientists will receive both financial and scientific support for their crop science research proposal / Successful projects have the potential to become future collaborations with Bayer / Researchers selected from more than 600 proposals representing 39 countries.

Research 52

Research Cell Biology Science Disease 52

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind are probably viruses and bacteria. James Inglese, a researcher at NIH’s National Center for Advancing Translational Sciences, and his colleagues decided to take another look. Nat Commun.

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Small Molecule Science Drug Development Disease 52

Drug Target Review

AUGUST 10, 2023

This discovery sheds new light on the intricate mechanisms at play within cancer cells when faced with adverse conditions. Metastasis is the most lethal attribute of cancer cells and clinical decisions regarding treatment are based largely upon the likelihood of developing metastases.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

DrugBank

JUNE 27, 2023

Out of the millions of genetic variants present in human populations, GWAS are designed to uncover those associated with specific traits or diseases. 9 Polygenic diseases are much more common, and thousands of genetic variants with very small effects could impact their phenotype.

Disease 98

Disease Treatment Drugs Clinical Trials 98

The Pharma Data

OCTOBER 27, 2021

million expansion will bring high quality seeds to worldwide markets faster, providing solutions for growers and meeting consumer demands / The seven-hectare global Product Design Center in San Nicolás includes state-of-the-art lab space for cell biology research and greenhouses for seed production.

Cell Biology 40

Cell Biology Production Laboratories Marketing 40

Elrig

APRIL 29, 2024

My role involved generating and characterizing complex proteins critical for biological assay development, hit discovery, and structural biology. During this time, I had the opportunity to step in as an interim Discovery Sciences project lead, sparking my interest in project leadership.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

The Pharma Data

MARCH 11, 2021

Speaking at the virtual Capital Markets Day on Wednesday, CEO Werner Baumann emphasized Bayer’s long-term growth perspectives: “Bayer is a leading life science company, uniquely positioned at the intersection of health and nutrition – with attractive prospects for growth, earnings and cash flow.”

Science 52

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The Pharma Data

OCTOBER 19, 2020

an emerging leader focused on the treatment of kidney disease, sepsis and organ injury, today announced the appointment of Maarten Kraan, M.D., in Cell Biology from Utrecht University. AM-Pharma’s purpose is to save and improve the lives of patients confronted with kidney disease, sepsis and organ injury.

Trials 40

Trials Small Molecule Cell Biology Clinical Trials 40

The Pharma Data

DECEMBER 31, 2020

Among people with severe disease, some die and some recover. A group of researchers at The Korean Advanced Institute of Science and Technology (KAIST) have found the underlying mechanism of plasticity, which could be related to neurological disorders in adult brains. So, there are a lot of other things going on.

Research 52

Research Virus Immune Response Cell Biology 52

The Pharma Data

JANUARY 3, 2021

He brings extensive life sciences experience to the Company, gained primarily through his nearly 20-year career at Celgene where he built the medical infrastructure as the company evolved. At NexImmune, he will oversee all aspects of research and development. For more information, visit www.neximmune.com.

Immune Response 40

Immune Response Clinical Trials Therapies Cell Biology 40

Codon

APRIL 9, 2023

“Computer science is to biology what calculus is to physics.” Read Basic Science *mRNA decoding in human is kinetically and structurally distinct from bacteria. Read *T(STEM)-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models.

Therapies 52

Therapies RNA Engineering Vaccine 52

Drug Target Review

JANUARY 30, 2024

About the author Dr Jia-Jia Zhang, Doctoral candidate Dr Jia-Jia Zhang is a doctoral candidate at the National Translational Science Center for Molecular Medicine & Department of Cell Biology, Fourth Military Medical University, and her research interest is the development of therapeutical antibodies to treat human disease.

Treatment 52

Treatment Doctors Cell Biology Regulations 52

Codon

APRIL 30, 2023

But if you start to play with the times during which these genes are expressed, you can make cells age differently. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. Read more at Science. Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

But if you start to play with the times during which these genes are expressed, you can make cells age differently. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. Read more at Science. Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 2, 2023

Basic Science *No evidence for a common blood microbiome based on a population study of 9,770 healthy humans. Read Health *Base editing rescue of spinal muscular atrophy in cells and in mice. Mice and human cells that were given the therapy had normal levels of the survival motor neuron protein, and no symptoms. Ricciardi M.J.

DNA 52

DNA RNA Engineering Licensing 52

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

APRIL 9, 2024

“Cumulatively the deadliest of the human infectious diseases,” malaria has been documented throughout recorded history. It established the Leading Group of the National Malaria Research Team, with members from the Ministry of Health, the Ministry of Chemical Industry, and the Chinese Academy of Sciences.

Drugs 137

Drugs Science Research Doctors 137

Broad Institute

JULY 28, 2023

Neurobiology & Organismal Biology By Maria Nemchuk July 28, 2023 Breadcrumb Home Neurobiology & Organismal Biology Takao Hensch, Harvard/Boston Children’s Hospital Takao Hensch Takao Hensch Takao Hensch , Ph.D. in molecular and cell biology and biochemistry from the University of Oxford.

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Medical Schools Hospitals Regulations Research 52

Drug Target Review

APRIL 1, 2025

Advances in biotechnology are driving significant progress in the treatment of rare diseases, making it possible to develop targeted therapies for previously untreatable conditions. I then took over management of a research group, initially running cell biology research and then preclinical development.” billion by 2032.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

BMG Labtech

FEBRUARY 24, 2025

The introduction of a nitro- group into a protein molecule is also implicated in different diseases including cardiovascular disease , lung disease, diabetes, cancer and some neurodegenerative conditions. While protein nitration is linked to disease, in many cases its precise physiological function is often unknown.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

Drug Target Review

JANUARY 16, 2025

These sites are commonly involved in protein-protein interactions, some of which are key to disease development. Food and Drug Administration (FDA) approved drugs, macrocycles are used to combat a range of diseases, including cancer, viral, fungal and bacterial infections, neurodegenerative and autoimmune diseases.

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