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In this article, we will delve into the world of condensate biology and explore the groundbreaking research projects undertaken to discover the potential they hold for diseases such as amyotrophic lateral sclerosis ( ALS ) and colorectal cancer. Klein notes the importance of Dewpoint’s disease-agnostic approach.
Shortly after finishing my studies, I landed my first job in industry working on cellbiology research for several disease indications. TPD engages the body’s natural protein recycling system by selectively eliminating disease-causing proteins, ultimately addressing the root cause of disease.
2 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. 1-5 Implication of ATX in a large range of human diseases have been highlighted by both fundamental research and clinical trials. The Journal of CellBiology. 2002 Jul 22;158(2):227–33.
Published in the Proceedings of the National Academy of Sciences , a new discovery from the University of Southern California (USC) on cancer metastasis has opened up new possibilities for combating the spread of this devastating disease.
Fascinated by the potential of AI in medical research, I transitioned to BenevolentAI in early 2023 as a Biology Project Leader. There, I supported AI-enabled DD efforts in their smallmolecule portfolio. Driven by an interest in drug discovery Millie joined AstraZeneca after completion of her PhD at the end of 2020.
All of these are novel targets to be explored in smallmolecule drug discovery as well as for improving the efficacy of mRNA vaccines. However, our inability to understand that biology is what stands in the way of further progress. And since mRNA biology is like the highway of cellbiology, it would likely be visible there.
Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind are probably viruses and bacteria. Missing was the usual pocket-shaped active site, where a traditional smallmolecule can readily bind and block function. ” [1] Or was it?
an emerging leader focused on the treatment of kidney disease, sepsis and organ injury, today announced the appointment of Maarten Kraan, M.D., At Aduro, he was responsible for all manufacturing and supply chain activities for the company’s biologics and smallmolecules and managed a transatlantic team. 20, 2020 09:00 UTC.
An open-source FACS automation system for high-throughput cellbiology. Cell Systems. Read Small-molecule aptamer for regulating RNA functions in mammalian cells and animals. Read The FDA is reviewing a “controversial cell therapy for ALS,” developed by BrainStorm Cell Therapeutics.
If these printers were set up in resource-starved countries, where malaria and other diseases are endemic, they could make a world of difference. 5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. Nature CellBiology. Cell Systems.
If these printers were set up in resource-starved countries, where malaria and other diseases are endemic, they could make a world of difference. 5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. Nature CellBiology. Cell Systems.
Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 2 Typically, small-molecule drugs target active sites buried inside proteins. However, it remains challenging to design antibodies that cross cell membranes.
Nature CellBiology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. The Lancet Infectious Diseases. The Lancet Infectious Diseases. Read Sana Biotechnology , a company that is engineering cells to treat diseases, saw its stock rise 49.4% million ($1.58
Even their most notorious manifestation, Mad Cow Disease , seems a cautionary tale about contaminated beef rather than a window into one of biology's most fascinating mechanisms. These fibrils disrupt normal cellular function, producing irreversible diseased states. Prion protein aggregates (red) inside mouse nerve cells.
The introduction of a nitro- group into a protein molecule is also implicated in different diseases including cardiovascular disease , lung disease, diabetes, cancer and some neurodegenerative conditions. While protein nitration is linked to disease, in many cases its precise physiological function is often unknown.
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