Drug Target Review

JUNE 5, 2023

There is a high unmet medical need in this area because while other candidates have shown early signs of clinical activity, there is still a need for therapies with improved safety and efficacy profiles. Mesothelin (MSLN) is overexpressed in many cancer indications, including pancreatic, mesothelioma and ovarian.

Treatment 100

Treatment Pharmacokinetics Drugs Cell Biology 100

Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

Cell Biology 107

Cell Biology Pharmaceuticals Science Disease 107

Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. TPD engages the body’s natural protein recycling system by selectively eliminating disease-causing proteins, ultimately addressing the root cause of disease.

Small Molecule 116

Small Molecule Targeted Protein Degradation Science Disease 116

Drug Target Review

JUNE 29, 2023

I think the cell-therapy field has evolved a lot – and is continuing to do so – in the time I’ve been working with this. Regarding the NY-ESO programme that we worked on, I started work on that in 2002 before we even knew that we were going to do cell therapy.

Therapies 115

Therapies Science Production Cell Biology 115

Codon

APRIL 9, 2023

“Computer science is to biology what calculus is to physics.” ” — Harold Morowitz 🔥 Ten Amazing Things (that happened this week…) A CAR-T therapy was tested in 27 children with neuroblastomas. The CAR-T cells were detectable in 26 out of 27 children after 30 months. Molecular Therapy.

Therapies 52

Therapies RNA Engineering Vaccine 52

Drug Target Review

AUGUST 24, 2023

Neutralising GDF-15 with CatalYm’s anti-GDF-15 antibody visugromab was shown to reverse its inhibitory effects and to re-sensitise tumours to anti-PD-1 treatment, achieving commensurate survival benefit of anti-GDF-15-anti-PD-1 combination therapy in vivo. Current Opinion in Cell Biology. Biophysical Journal.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

PerkinElmer

JANUARY 21, 2022

1 To address the urgent need for new therapies, the UK’s Medical Research Council (MRC), a national public agency supporting health science and research, established the Dementias Platform United Kingdom (DPUK) in 2014. Of these, around 850,000 live in the United Kingdom (UK) at an annual care cost of £26 billion (US$38 billion).

Cell Biology 52

Cell Biology Disease Treatment Science 52

Drug Target Review

APRIL 9, 2024

How has nucleolar stress (NS) been linked to age-related diseases, and what approach did researchers use to investigate its toxicity? The nucleolus (and nucleolar stress) had been previously linked to aging and age-related diseases such as cancer or degeneration.

RNA 64

RNA Cell Biology Clinical Development DNA 64

The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g.

Cell Biology 52

Cell Biology Molecular Biology Science Laboratories 52

DrugBank

JUNE 27, 2023

Out of the millions of genetic variants present in human populations, GWAS are designed to uncover those associated with specific traits or diseases. Their use, as well as their integration into other types of data, has enabled the development of more precise therapies.

Disease 87

Disease Treatment Drugs Clinical Trials 87

The Pharma Data

JANUARY 3, 2021

“Both Jerry and Jeff have proven and successful track records in the design and execution of early and late-stage clinical trials that have evaluated novel immune therapies. It is my privilege to advise NexImmune as it seeks to develop novel treatments for melanoma and other cancers,” stated Dr. Weber.

Immune Response 40

Immune Response Clinical Trials Therapies Cell Biology 40

Codon

APRIL 30, 2023

If these printers were set up in resource-starved countries, where malaria and other diseases are endemic, they could make a world of difference. 5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

If these printers were set up in resource-starved countries, where malaria and other diseases are endemic, they could make a world of difference. 5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. In the pharmaceutical sector, new technologies could help us not only to treat but probably cure or even prevent diseases,” Baumann said.

Science 52

Science Pharmaceuticals Licensing Licensing 52

Codon

APRIL 2, 2023

Read Health *Base editing rescue of spinal muscular atrophy in cells and in mice. Read A one-time gene therapy injection for spinal muscular atrophy. Mice and human cells that were given the therapy had normal levels of the survival motor neuron protein, and no symptoms. Gene Therapy. Trends in Biotechnology.

DNA 52

DNA RNA Engineering Licensing 52

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

APRIL 9, 2024

“Cumulatively the deadliest of the human infectious diseases,” malaria has been documented throughout recorded history. In this light, scouring old Chinese remedies for new treatments for a disease specifically troublesome during war was entirely intuitive for Chinese biomedical scientists like Tu Youyou in the mid-20th century.

Drugs 134

Drugs Science Research Doctors 134

Codon

SEPTEMBER 22, 2024

They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days.

DNA 103

DNA Laboratories Regulations Therapies 103

Precision for Medicine

APRIL 7, 2023

Our new state-of-the-art laboratory, combined with the deep knowledge of our scientists, gives an advantage to clients developing novel therapeutics and diagnostic products in oncology, liver disease, and skin diseases. Senior Vice President at Precision for Medicine. “Our

Laboratories 52

Laboratories Clinical Research Clinical Trials Cell Biology 52

Broad Institute

NOVEMBER 21, 2024

Bernstein is also chair of the Department of Cancer Biology at Dana-Farber Cancer Institute, a professor in cell biology and pathology at Harvard Medical School, and holds the Richard and Nancy Lubin Family Chair. Inevitable progression Gliomas arise from glial cells, which protect and support a healthy nervous system.

Research 124

Research Medical Schools DNA Hospitals 124

Codon

APRIL 16, 2023

Compact gene editors , called enOsCas12f1 and enRhCas12f1, are smaller than many existing Cas proteins and can thus be more easily delivered in a single virus for gene therapies. By engineering the sgRNA and optimizing these proteins, new variants had high editing efficiencies and low off-target effects in human cells. Cell Reports.

Engineering 52

Engineering DNA RNA Science 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 95

DNA Cell Biology Molecular Biology Engineering 95

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

NOVEMBER 1, 2024

Amodei also imagines the ways AI could accelerate biological research and yield miraculous cures in the 21st century; everything from the prevention and treatment of nearly all infectious and inherited diseases to the elimination of most cancers. This essay focuses on how we might do both, specifically for the cell. Even the humble E.

DNA 114

DNA RNA Molecular Biology Laboratories 114