KIF1A

MAY 24, 2023

In this blog post, KIF1A.ORG Chief Science Officer Dr. Dominique Lessard describes a unique cross disciplinary experience with multiple scientific stakeholders in the rare disease space, all focused around our holistic understanding of KAND. How do we move the needle to make patient voices and experiences the center of scientific discovery?

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Drug Target Review

JUNE 7, 2024

The proof for this came with the approval of KIMMTRAK (tebentafusp-tebn) by the FDA in 2022 for the treatment of HLA-A*02:01+ metastatic or unresectable uveal melanoma, a historically “cold” tumour known to be resistant to current available checkpoint immunotherapies.

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Drug Target Review

OCTOBER 31, 2023

When I was studying cell biology, looking at how cells divide, I couldn’t fathom how math could possibly fit into that. My undergraduate studies focused on biochemistry and cell biology, so very much STEM-based, but my professors and mentors noticed my penchant for critical thinking which led me to consider law.

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Cell Biology Pharmaceuticals Science Disease 108

Drug Target Review

AUGUST 24, 2023

We will explore how GDF-15 impacts the tumour microenvironment and hinders the infiltration of T cells into the tumour, as well as the implications of neutralising GDF-15 to reverse its inhibitory effects and sensitise tumours to anti-PD-1 treatment. T-cell infiltration is a prerequisite for responses to checkpoint inhibitors.

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DrugBank

JUNE 27, 2023

The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care.

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Drug Target Review

JANUARY 30, 2024

Adenylyl cyclase superactivation induced by long-term treatment with opioid agonist is dependent on receptor localized within lipid rafts and is independent of receptor internalization. Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons. Br J Pharmacol. 2012;165(6):1704-16. Mol Pharmacol.

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Broad Institute

FEBRUARY 29, 2024

He joined the platform in December 2023 and his interest lies in using spatial transcriptomics sequencing methods to study psychiatric disease. He hopes to model and investigate drug responses in diseased neuronal systems, ultimately aiming to improve mental health treatments that have stalled in recent decades.

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Cell Biology Disease Science Treatment 52

Drug Target Review

AUGUST 10, 2023

Published in the Proceedings of the National Academy of Sciences , a new discovery from the University of Southern California (USC) on cancer metastasis has opened up new possibilities for combating the spread of this devastating disease.

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Drug Target Review

MAY 22, 2023

Dr Susanne Rafelski, who led the study, spoke with Drug Target Review about how the study was conducted, how it might apply to diseases, and future directions. This project started in the early days of the Allen Institute for Cell Science, nearly seven years ago. In disease, what goes wrong in cells can often be seen by eye.

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The Pharma Data

JANUARY 3, 2021

“I look forward to working with Scott and his team at NexImmune to help advance and expand the Company’s research and development pipeline with the ultimate goal of developing next-generation immunotherapies for patients suffering from immune-mediated conditions related to cancers and autoimmune/inflammatory diseases,” Dr. Zeldis commented. “It

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Immune Response Clinical Trials Therapies Cell Biology 40

New Drug Approvals

JANUARY 9, 2024

The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. Recent genetic and biochemical studies have confirmed the importance of CDK7 for cell cycle progression (Larochelle.

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Drug Target Review

JUNE 5, 2023

It also supports the argument for developing ZW171 for the treatment of other MLSN-expressing solid tumours. What is the significance of ZW191 demonstrating strong responses in FRα-low expressing PDX models for the treatment of oncology indications with lower levels of FRα?

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Drug Target Review

OCTOBER 2, 2024

Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. Early-phase clinical trials have shown the safety and efficacy of using stem cells for cardiac repair, encouraging further research and development.

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Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. His mother had a presentation of the disease that suggested her immune system was already on the job.

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Codon

APRIL 9, 2024

“Cumulatively the deadliest of the human infectious diseases,” malaria has been documented throughout recorded history. In response to the precipitous rise in incidence, governments on both sides of the Pacific began a systematized search for antimalarial treatments. Subscribe to receive essays from Asimov Press.

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Drugs Science Research Doctors 139

PerkinElmer

JANUARY 21, 2022

DPUK became the world’s largest collaborative research organization focused on early detection, better treatment, and prevention of neurodegenerative conditions. Gallacher said that researchers need to identify and then measure biomarkers for disease, so they can then identify what changes over time. “By That’s right, the MRC says.

Cell Biology 52

Cell Biology Disease Treatment Science 52

Drug Target Review

JUNE 29, 2023

Obviously there are lots of issues to work on, but it’s a real modality that is changing people’s lives for the long term and changing the way we think about cancer treatments. When it comes down to cell biology itself, cells can do so many different things.

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Therapies Science Production Cell Biology 116

Drug Target Review

DECEMBER 21, 2023

And really, this comes to the biggest question of all: what is the underlying mechanism of a given disease? There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype. And this is exactly where AI can provide us with an extremely powerful new strategy.

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The Pharma Data

OCTOBER 19, 2020

an emerging leader focused on the treatment of kidney disease, sepsis and organ injury, today announced the appointment of Maarten Kraan, M.D., in Cell Biology from Utrecht University. AM-Pharma’s purpose is to save and improve the lives of patients confronted with kidney disease, sepsis and organ injury.

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NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Credit: National Center for Advancing Translational Sciences, NIH When you think of the causes of infectious diseases, what first comes to mind are probably viruses and bacteria. Now, NIH researchers and their collaborators have discovered a new kind of treatment that holds promise for fighting parasitic roundworms. Nat Commun.

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The Pharma Data

DECEMBER 31, 2020

Among people with severe disease, some die and some recover. Adult brains undergo similar treatment, but it’s not well understood why adult synapses are eliminated. Now colleagues all over the country who are investigating various aspects of health and disease using rhesus macaques can begin to make use of that information.”.

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Precision for Medicine

APRIL 7, 2023

Our new state-of-the-art laboratory, combined with the deep knowledge of our scientists, gives an advantage to clients developing novel therapeutics and diagnostic products in oncology, liver disease, and skin diseases. Senior Vice President at Precision for Medicine.

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The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. In the pharmaceutical sector, new technologies could help us not only to treat but probably cure or even prevent diseases,” Baumann said.

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Codon

APRIL 2, 2023

Mice and human cells that were given the therapy had normal levels of the survival motor neuron protein, and no symptoms. When delivered using AAV9 in mice, the treatment significantly improved motor function and extended average lifespan. An open-source FACS automation system for high-throughput cell biology. Wiener D.M.

DNA 52

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Broad Institute

JULY 28, 2023

Through his comprehensive investigations, he strives to advance knowledge and identify potential therapeutic interventions for stress-related psychiatric disorders and neurodegenerative diseases. The Sabatini Lab focuses on the development and regulation of synapses in the brain and the relationship of these processes to behavior and disease.

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Codon

APRIL 30, 2023

If these printers were set up in resource-starved countries, where malaria and other diseases are endemic, they could make a world of difference. 5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. Nature Cell Biology. vander Straeten et al.

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Codon

APRIL 30, 2023

If these printers were set up in resource-starved countries, where malaria and other diseases are endemic, they could make a world of difference. 5/ Lots O’ Gene Therapies Not one, but two applications for sickle-cell gene therapies have been submitted to the F.D.A. Nature Cell Biology. vander Straeten et al.

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Codon

APRIL 9, 2023

The CAR-T cells were detectable in 26 out of 27 children after 30 months. Of those, 17 children responded to the treatment, and the 3-year overall survival rate was 60 percent. Read Longevity Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality. Nature Cell Biology.

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Codon

SEPTEMBER 22, 2024

They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days.

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The Pharma Data

NOVEMBER 17, 2021

Every day, hundreds of thousands of new COVID-19 cases and thousands of new deaths are still being reported worldwide, creating a need for drugs that can combat the disease caused by SARS-CoV-2. The drug is FDA-approved and has been prescribed for over 60 years as a treatment for alcoholism. In the retrospective study, published Oct.

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Drug Target Review

APRIL 1, 2025

Advances in biotechnology are driving significant progress in the treatment of rare diseases, making it possible to develop targeted therapies for previously untreatable conditions. I then took over management of a research group, initially running cell biology research and then preclinical development.”

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Codon

APRIL 16, 2023

Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. The Lancet Infectious Diseases. The Lancet Infectious Diseases. Cell Reports. Read Sana Biotechnology , a company that is engineering cells to treat diseases, saw its stock rise 49.4%

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Codon

APRIL 8, 2025

Even their most notorious manifestation, Mad Cow Disease , seems a cautionary tale about contaminated beef rather than a window into one of biology's most fascinating mechanisms. These fibrils disrupt normal cellular function, producing irreversible diseased states. Prion protein aggregates (red) inside mouse nerve cells.

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Broad Institute

NOVEMBER 21, 2024

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations.

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BMG Labtech

FEBRUARY 24, 2025

The introduction of a nitro- group into a protein molecule is also implicated in different diseases including cardiovascular disease , lung disease, diabetes, cancer and some neurodegenerative conditions. While protein nitration is linked to disease, in many cases its precise physiological function is often unknown.

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Codon

NOVEMBER 1, 2024

Amodei also imagines the ways AI could accelerate biological research and yield miraculous cures in the 21st century; everything from the prevention and treatment of nearly all infectious and inherited diseases to the elimination of most cancers. This essay focuses on how we might do both, specifically for the cell.

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