Broad Institute

MARCH 25, 2024

in cell biology. During graduate school at MIT and the Whitehead Institute, my interest in cell division came full circle and I was able to explore how a cell divides to make two cells that are genetically identical. Each cell needs the same amount of DNA so they can function like each other.

Science 111

Science Cell Biology Research DNA 111

Drug Target Review

OCTOBER 2, 2024

For example, integrating gene therapies that alter the DNA of cardiac cells pose risks of unintended genetic modifications, which could lead to tumorigenesis. Continued growth in the field relies on multidisciplinary efforts combining biology, engineering, and clinical medicine.

Therapies 98

Therapies Disease Engineering RNA 98

The Pharma Data

MARCH 15, 2022

. “The problem is that cells only make small amounts of p53 and then quickly break it down as it is a very large and disordered protein,” says the study’s last author Michael Landreh, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet.

Cell Biology 52

Cell Biology DNA Research Vaccine 52

Dark Matter Blog

APRIL 4, 2023

The tools in this kit fall into a few broad categories: understanding protein structures and their functional significance, identifying ligands that bind into functionally significant pockets, and developing assays that confirm target engagement along with demonstrating the anticipated impact on cell biology.

Small Molecule 52

Small Molecule RNA Fragment Screening DNA 52

Codon

APRIL 30, 2023

2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. kilobases” of DNA into a plant genome. (My Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. kilobases” of DNA into a plant genome. (My Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Elrig

APRIL 29, 2024

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Codon

APRIL 9, 2023

.” This technology could be used to design protein therapeutics that can bind to, and “shut down,” harmful or misfolded proteins in living cells. Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Nature Cell Biology.

Therapies 52

Therapies RNA Engineering Vaccine 52

BMG Labtech

MARCH 8, 2023

DNA, proteins, polysaccharides, etc.). Cells require energy for this process. 2 Organisms are categorised based on their anabolism and according to the source used by cells to build-up molecules. Anabolism consists of three basic steps: the production of precursor molecules (e.g., nucleotides, monosaccharides, etc.),

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

DrugBank

JUNE 27, 2023

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., Network expansion of genetic associations defines a pleiotropy map of human cell biology. Coding mutations have a more direct effect through direct alteration of a gene product.

Disease 88

Disease Treatment Drugs Clinical Trials 88

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Codon

SEPTEMBER 22, 2024

During this process, the cells’ genomes ditch their methyl groups, an important epigenetic mark. Erasing methyl groups on DNA is necessary for normal egg and sperm development. Reaching the oogonia stage marked an impressive achievement in germ cell biology, because previous methods only went up to the PGC stage.

DNA 98

DNA Laboratories Regulations Therapies 98

Codon

FEBRUARY 28, 2023

1 One rarely pauses to ponder how so much DNA — let alone sugar, proteins, and everything else — can fit inside such a small vessel. Biochemistry textbooks depict cells as spacious places, where molecules float in secluded harmony. Without mathematics, I learned, biology is naked; we can only comprehend it at arm's length.

RNA 52

RNA DNA Cell Biology Small Molecule 52

Codon

NOVEMBER 1, 2024

For example, cloning DNA molecules and inserting them into cells — a process required for basically all experiments in molecular biology — takes up to a week of work. But looking ahead to the second bottleneck, what does it mean to say that biology is “complex”? Even the humble E.

DNA 109

DNA RNA Molecular Biology Laboratories 109

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 93

DNA Cell Biology Molecular Biology Engineering 93

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 16, 2023

Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. Perhaps there is now a way to use DNA to extract metals: You could fuse the DNA strands to an antibody, coat them onto electronics, and then use a column to isolate the DNA:metal compounds? Nature Chemical Biology.

Engineering 52

Engineering DNA RNA Science 52