Drug Discovery World

AUGUST 10, 2023

ND : Totus has innovated three interdependent and fundamental technologies in chemistry, biology, and AI to enable screening of billions of candidate molecules against hundreds of targets in parallel. Second, we have created a novel DNA-tracking technology to analyse billions of molecular interaction in a cellular setting.

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Small Molecule Clinical Trials Cell Biology Disease 130

Drug Discovery World

OCTOBER 18, 2023

in Cell Biology and Biochemistry from University College London and was a post-doctoral fellow at Albert Einstein College of Medicine in New York City. Such therapies have become an appealing drug modality for multiple conditions, including monogenic disorders, cancers, and infectious diseases. She received a Ph.D. References 1: U.S.

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Therapies Clinical Trials FDA Approval Virus 162

Drug Target Review

JULY 31, 2023

For my PhD project, I chose an advisor who worked on DNA and I started working with her on the physical properties of DNA. I worked with Jackie Barton in the early days of what’s now called DNA-mediated electron transfer. And that was a very controversial idea.

DNA 98

DNA Small Molecule Science Cell Biology 98

Drug Target Review

APRIL 9, 2024

For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX. In 2005, he joined CNIO to lead the Genomic Instability Group where he has been ever since.

RNA 63

RNA Cell Biology Clinical Development DNA 63

Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. They tend to “group up” in cells. Molecular Systems Biology. Nature Microbiology. Meeussen J.V.W.

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Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. When I began my PhD I completely switched my focus, and I haven’t looked back,” said Manguso.

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Research Immune Response Clinical Trials Cell Biology 137

Codon

FEBRUARY 20, 2024

Collecting the Numbers We can easily measure some things in biology yet struggle to measure others. Thanks to decades of progress in molecular sequencing technologies, it is simple to read out the order of nucleotides in a DNA sequence, for example, or to quantify messenger RNAs as they are made by a cell.

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RNA DNA Engineering Cell Biology 98

Broad Institute

MARCH 25, 2024

in cell biology. During graduate school at MIT and the Whitehead Institute, my interest in cell division came full circle and I was able to explore how a cell divides to make two cells that are genetically identical. Each cell needs the same amount of DNA so they can function like each other.

Science 112

Science Cell Biology Research DNA 112

Codon

APRIL 16, 2023

Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. Perhaps there is now a way to use DNA to extract metals: You could fuse the DNA strands to an antibody, coat them onto electronics, and then use a column to isolate the DNA:metal compounds? Nature Chemical Biology.

Engineering 52

Engineering DNA RNA Science 52

Dark Matter Blog

APRIL 4, 2023

The tools in this kit fall into a few broad categories: understanding protein structures and their functional significance, identifying ligands that bind into functionally significant pockets, and developing assays that confirm target engagement along with demonstrating the anticipated impact on cell biology.

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The Pharma Data

MARCH 15, 2022

. “The problem is that cells only make small amounts of p53 and then quickly break it down as it is a very large and disordered protein,” says the study’s last author Michael Landreh, researcher at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet.

Cell Biology 52

Cell Biology DNA Research Vaccine 52

Codon

APRIL 30, 2023

2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. kilobases” of DNA into a plant genome. (My Nature Cell Biology.

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Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. kilobases” of DNA into a plant genome. (My Nature Cell Biology.

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Vaccine DNA Engineering RNA 52

Drug Discovery World

APRIL 14, 2023

He is being recognised for his fundamental discoveries dedicated to characterising the genetic drivers of human B-cell lymphomas and for uncovering new avenues for cancer prevention and therapy that have been routinely exploited clinically to diagnose and determine novel therapeutic strategies for B-cell lymphoma.

Clinical Trials 130

Clinical Trials Research Science Clinical Research 130

Elrig

APRIL 29, 2024

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing.

Bioinformatics 59

Bioinformatics Molecular Biology Drugs Cell Based Assays 59

Drug Discovery World

NOVEMBER 13, 2023

Steven Quistad, PhD, Senior Applications Scientist, DNA Script, on: ‘Rapidly assemble genes in your laboratory using automated enzymatic oligo synthesis’. Vaccines In his session, there will be two presentations following chairperson’s remarks from Viktor Lemgart, PhD, Research Fellow, Tidal Therapeutics, a Sanofi Company.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Drug Discovery World

OCTOBER 14, 2022

Lundblad, Drug Design, in Encyclopedia of Cell Biology (Volume 1), Elsevier, 2016. Büttner, MALDI-TOF mass spectrometry-based high-throughput screening for inhibitors of the cytosolic DNA sensor cGAS, SLAS Discovery, 2020, 25: 372–383, [link]. References . Attene-Ramos and M. Elsen and J.D. Zuvela-Jelaska, T. Bretschneider, A.H.

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Synthetic Chemistry Cell Based Assays Biochemical Assays Analytical Chemistry 130

Codon

APRIL 9, 2023

.” This technology could be used to design protein therapeutics that can bind to, and “shut down,” harmful or misfolded proteins in living cells. Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Nature Cell Biology.

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Therapies RNA Engineering Vaccine 52

BMG Labtech

MARCH 8, 2023

DNA, proteins, polysaccharides, etc.). Cells require energy for this process. 2 Organisms are categorised based on their anabolism and according to the source used by cells to build-up molecules. Anabolism consists of three basic steps: the production of precursor molecules (e.g., nucleotides, monosaccharides, etc.),

Molecular Biology 52

Molecular Biology Production Cell Based Assays DNA 52

DrugBank

JUNE 27, 2023

In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., Network expansion of genetic associations defines a pleiotropy map of human cell biology. Coding mutations have a more direct effect through direct alteration of a gene product.

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Disease Treatment Drugs DNA 89

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

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