Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. These cells also express the Cas9 protein, which helps disable the genes targeted by the guide RNAs.

Research 137

Research Immune Response Clinical Trials Therapies 137

Codon

FEBRUARY 20, 2024

My search made me appreciate how remarkable it is that life functions at all, considering the chaotic conditions in which cells exist. It also gave me a new appreciation for biology, and the incredible exactitude that one must have to engineer it — let alone engineer it successfully. of a Boeing 737 jet engine.

RNA 98

RNA DNA Engineering Cell Biology 98

Drug Target Review

JULY 31, 2023

For my PhD project, I chose an advisor who worked on DNA and I started working with her on the physical properties of DNA. I worked with Jackie Barton in the early days of what’s now called DNA-mediated electron transfer. I went to Genentech and postdoc-ed for Jim Wells in protein engineering.

DNA 98

DNA Small Molecule Science Cell Biology 98

Drug Target Review

OCTOBER 2, 2024

The heart does have limited regenerative capacity, but not enough of the healthy cells that capable of restoring function, making it difficult to recover from injuries such as myocardial infarction. However, cell-based therapies are intended to leverage those healthy cells via transplant to regenerate damaged tissue.

Therapies 98

Therapies Disease Engineering RNA 98

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Molecular Systems Biology.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) How to make a cell-penetrating Cas9 protein, and then incubate it with peptides to edit human cells. 2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Nature Biomedical Engineering.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) How to make a cell-penetrating Cas9 protein, and then incubate it with peptides to edit human cells. 2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Nature Biomedical Engineering.

Vaccine 52

Vaccine DNA Engineering RNA 52