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Reinventing the small molecule toolbox: from proteins to RNA

Dark Matter Blog

The tools in this kit fall into a few broad categories: understanding protein structures and their functional significance, identifying ligands that bind into functionally significant pockets, and developing assays that confirm target engagement along with demonstrating the anticipated impact on cell biology.

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Codon Digest: Injected Gene Editors

Codon

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. They tend to “group up” in cells. Molecular Systems Biology. Nature Microbiology. Meeussen J.V.W.

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Levers for Biological Progress

Codon

For example, cloning DNA molecules and inserting them into cells — a process required for basically all experiments in molecular biology — takes up to a week of work. But looking ahead to the second bottleneck, what does it mean to say that biology is “complex”? Even the humble E.

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