DrugBank

JUNE 27, 2023

Coding mutations have a more direct effect through direct alteration of a gene product. In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g., Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Disease 98

Disease Treatment Drugs Clinical Trials 98

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. When I began my PhD I completely switched my focus, and I haven’t looked back,” said Manguso.

Research 137

Research Immune Response Clinical Trials Therapies 137

Drug Target Review

OCTOBER 2, 2024

RNA-based therapies, including mRNA and RNA interference (RNAi), are being explored to modulate gene expression in heart cells. For instance, mRNA therapies can promote the production of specific proteins required for heart tissue repair, while RNAi can silence harmful gene expression, such as those driving fibrosis in heart failure.

Therapies 98

Therapies Disease Engineering RNA 98

Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. They tend to “group up” in cells. Molecular Systems Biology. Nature Microbiology. Meeussen J.V.W.

DNA 52

DNA RNA Engineering Licensing 52

BMG Labtech

MARCH 8, 2023

This coordinated series of biochemical reactions where the product of one conversion becomes the substrate for another reaction is known as metabolic pathways. Metabolism also includes the disposal of waste and by-products. In the cell, these macromolecules are synthesized in a step-by-step process from simple precursors.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

APRIL 9, 2023

.” This technology could be used to design protein therapeutics that can bind to, and “shut down,” harmful or misfolded proteins in living cells. Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Nature Cell Biology.

Therapies 52

Therapies RNA Engineering Vaccine 52