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Researchers identify source of a brain cancer’s deadly transformation

Broad Institute

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations.

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A research team searches for every gene that helps tumors evade immunotherapy

Broad Institute

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. Omar Avila Monge puts samples — immune cells isolated from tumors treated with the PTPN2 inhibitor — into a centrifuge.

Research 137
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#WhyIScience Q&A: A cell biologist now helps recent college graduates launch their scientific careers

Broad Institute

Navarro later became the first in her family to attend a four-year college, earning her degree in microbiology from the University of Texas at El Paso, followed by a stint doing research at Novartis in Cambridge, MA, and then graduate studies at MIT to earn her Ph.D. in cell biology. Why do you think it works?,”

Science 111
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Women in STEM July: Meet Michelle Arkin

Drug Target Review

For my PhD project, I chose an advisor who worked on DNA and I started working with her on the physical properties of DNA. Could you share an example of a specific project or some research that you have worked on and its impact in your field? In chemical biology, we are in a golden age.

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Fast Biology

Codon

Collecting the Numbers We can easily measure some things in biology yet struggle to measure others. Thanks to decades of progress in molecular sequencing technologies, it is simple to read out the order of nucleotides in a DNA sequence, for example, or to quantify messenger RNAs as they are made by a cell.

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What Limits a Genome’s Size?

Codon

And what they found, remarkably, is the world’s largest genome ; each fern cell contains 160.45 billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end.

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How nucleolar stress accelerates aging in mice

Drug Target Review

How has nucleolar stress (NS) been linked to age-related diseases, and what approach did researchers use to investigate its toxicity? For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX.

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