The Pharma Data

MARCH 15, 2022

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilising the protein and making it more potent.

Cell Biology 52

Cell Biology DNA Research Vaccine 52

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. Omar Avila Monge puts samples — immune cells isolated from tumors treated with the PTPN2 inhibitor — into a centrifuge.

Research 137

Research Immune Response Clinical Trials Cell Biology 137

Drug Discovery World

DECEMBER 15, 2022

As gene editing technologies like CRISPR progress toward clinical study, researchers must continue to advance new approaches and address inherent challenges, explains Jon Chesnut, PhD, Senior Director, Cell Biology R&D, Thermo Fisher Scientific. Reduce/eliminate chromosomal disruptions caused by double-strand DNA breaks.

DNA 130

DNA Clinical Trials Therapies RNA 130

Codon

JUNE 13, 2024

And what they found, remarkably, is the world’s largest genome ; each fern cell contains 160.45 billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end.

DNA 62

DNA Molecular Biology Virus Cell Biology 62

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Nucleic Acids Research. Cummins M.C.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 30, 2023

2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. kilobases” of DNA into a plant genome. (My Nature Cell Biology.

Vaccine 52

Vaccine Engineering DNA RNA 52

Codon

APRIL 30, 2023

2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Yeast die for two reasons: Either their nucleolus (where the DNA is kept) degrades and dies, or their mitochondria whimpers out and they stop making energy. kilobases” of DNA into a plant genome. (My Nature Cell Biology.

Vaccine 52

Vaccine Engineering DNA RNA 52

Drug Target Review

JULY 31, 2023

For my PhD project, I chose an advisor who worked on DNA and I started working with her on the physical properties of DNA. Could you share an example of a specific project or some research that you have worked on and its impact in your field? In chemical biology, we are in a golden age.

DNA 98

DNA Small Molecule Science Cell Biology 98

Codon

FEBRUARY 20, 2024

Collecting the Numbers We can easily measure some things in biology yet struggle to measure others. Thanks to decades of progress in molecular sequencing technologies, it is simple to read out the order of nucleotides in a DNA sequence, for example, or to quantify messenger RNAs as they are made by a cell.

RNA 98

RNA DNA Engineering Cell Biology 98

Drug Discovery World

NOVEMBER 13, 2023

Thereafter, the following presentations will take place: Melody Shahsavarian, PhD, Digital Biologics Platform, Large Molecules Research, Sanofi, on: ‘Enhancing antibody discovery with generative AI’. Ali Madani, PhD, Founder and CEO, Profluent Bio, on: ‘Protein engineering with large language models’.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain.

Bioinformatics 59

Bioinformatics Molecular Biology Drugs Cell Based Assays 59

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

APRIL 9, 2023

This is Codon Digest, my weekly roundup of research, news, and industry highlights about the future of biology. ” This technology could be used to design protein therapeutics that can bind to, and “shut down,” harmful or misfolded proteins in living cells. Nucleic Acids Research. Nature Cell Biology.

Therapies 52

Therapies RNA Engineering Vaccine 52

DrugBank

JUNE 27, 2023

As researchers increased their ability to gather large amounts of genetic data, they gained the ability to study the genome as a whole, giving rise to the field of genomics. In contrast, non-coding mutations have effects on gene expression, transcript stability, and the physical state of the DNA itself (e.g.,

Disease 89

Disease Treatment Drugs International 89

Drug Discovery World

OCTOBER 14, 2022

Lundblad, Drug Design, in Encyclopedia of Cell Biology (Volume 1), Elsevier, 2016. Büttner, MALDI-TOF mass spectrometry-based high-throughput screening for inhibitors of the cytosolic DNA sensor cGAS, SLAS Discovery, 2020, 25: 372–383, [link]. References . Attene-Ramos and M. Elsen and J.D. Zuvela-Jelaska, T. Bretschneider, A.H.

Synthetic Chemistry 130

Synthetic Chemistry Cell Based Assays Biochemical Assays Analytical Chemistry 130

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 93

DNA Cell Biology Molecular Biology Engineering 93

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. It costs about $15 to sequence a DNA plasmid (if you use Plasmidsaurus ). Nature Chemical Biology. Mansilla S.F.

Engineering 52

Engineering DNA RNA Science 52