Drug Discovery World

OCTOBER 18, 2023

Sara Donnelly, Director of Research Planning and Business Development at PhoenixBio USA explores why the right pre-clinical model is essential for teams wanting to advance adeno-associated virus vector-based gene therapies. Adeno-associated virus (AAV) vector-based gene therapies hold exceptional promise across a range of disease areas.

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Therapies Clinical Trials FDA Approval Virus 162

Codon

JUNE 13, 2024

And what they found, remarkably, is the world’s largest genome ; each fern cell contains 160.45 billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end.

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DNA Molecular Biology Virus Cell Biology 62

Drug Discovery World

DECEMBER 15, 2022

As gene editing technologies like CRISPR progress toward clinical study, researchers must continue to advance new approaches and address inherent challenges, explains Jon Chesnut, PhD, Senior Director, Cell Biology R&D, Thermo Fisher Scientific. Reduce/eliminate chromosomal disruptions caused by double-strand DNA breaks.

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DNA Clinical Trials Therapies RNA 130

Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. They tend to “group up” in cells. Molecular Systems Biology. Nature Microbiology. Meeussen J.V.W.

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DNA RNA Engineering Licensing 52

Codon

APRIL 30, 2023

This works for many different cell types, and the method can also be used to deliver several different gene editors at once. It’s an easier way to get CRISPR into cells! Other methods to deliver Cas9 (like with viruses) are way less efficient, and seem to vary wildly from one cell to the next. From Zhang et al.

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Vaccine Engineering DNA RNA 52

Codon

APRIL 30, 2023

This works for many different cell types, and the method can also be used to deliver several different gene editors at once. It’s an easier way to get CRISPR into cells! Other methods to deliver Cas9 (like with viruses) are way less efficient, and seem to vary wildly from one cell to the next. From Zhang et al.

Vaccine 52

Vaccine Engineering DNA RNA 52

Codon

APRIL 9, 2023

.” This technology could be used to design protein therapeutics that can bind to, and “shut down,” harmful or misfolded proteins in living cells. Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Nature Cell Biology.

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Therapies RNA Engineering Vaccine 52