Drug Target Review

JULY 13, 2023

The company developed methods to identify disease-driving condensates, model them, and create systems for effective drug discovery targeting these condensates. The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0”

Disease 98

Disease Small Molecule Cell Biology Drugs 98

The Pharma Data

FEBRUARY 24, 2022

Researchers at the University of North Carolina at Chapel Hill and the UNC Lineberger Comprehensive Cancer Center have uncovered a new role of a chromatin-modulatory enzyme, termed EZH2, during cancer development. They then developed a new therapeutic approach with a potent small-molecule inhibitor of this enzyme.

Small Molecule 52

Small Molecule Cell Biology Research Drug Development 52

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Researchers soon began screening a chemical library and its more than 380,000 traditional drug candidates to find the right small-molecule inhibitor, the preferred compound in drug discovery. Missing was the usual pocket-shaped active site, where a traditional small molecule can readily bind and block function.

Small Molecule 52

Small Molecule Science Drug Development Disease 52

Elrig

APRIL 29, 2024

Fascinated by the potential of AI in medical research, I transitioned to BenevolentAI in early 2023 as a Biology Project Leader. There, I supported AI-enabled DD efforts in their small molecule portfolio. Driven by an interest in drug discovery Millie joined AstraZeneca after completion of her PhD at the end of 2020.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Drug Target Review

JANUARY 16, 2025

What are macrocycles and why are they interesting for drug discovery? Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 2 Typically, small-molecule drugs target active sites buried inside proteins.

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52