Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. These are two essential signalling nodes in genetically and clinically validated pathways driving inflammation in autoimmune diseases that are undrugged or inadequately drugged with other technologies.

Small Molecule 116

Small Molecule Targeted Protein Degradation Science Disease 116

Drug Target Review

NOVEMBER 1, 2023

Notably, it has been shown that LPA is a cell motility factor and inhibition of ATX results in a decrease of cellular invasion through a reduction of LPA concentration in the surrounding fluids in vitro. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production.

Clinical Trials 134

Clinical Trials Trials Small Molecule Disease 134

Elrig

APRIL 29, 2024

Webinar | Ai At The Frontier: Empowering Early Career Professionals In Drug Discovery WEBINAR – ARE YOU CURIOUS ABOUT THE CUTTING-EDGE INTERSECTION OF ARTIFICIAL INTELLIGENCE AND DRUG DISCOVERY? Are you curious about the cutting-edge intersection of Artificial Intelligence and Drug Discovery?

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Drug Target Review

SEPTEMBER 19, 2023

puts an end to the previous mandate that all drugs need to be tested on animals prior to human clinical trials. This major shift to the orthodox tradition of using animal experiments in drug testing dates back the Aristotle’s time and cemented 80 years ago with initial federal mandate of drug safety regulation of 1938.

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Animal Testing Clinical Trials Pharmaceutical Companies FDA 98

Broad Institute

FEBRUARY 29, 2024

He hopes to model and investigate drug responses in diseased neuronal systems, ultimately aiming to improve mental health treatments that have stalled in recent decades. During this time, he gained significant single-cell biology training through co-mentorship by Aviv Regev at the Klarman Cell Observatory.

Cell Biology 52

Cell Biology Disease Science Treatment 52

Drug Target Review

JUNE 7, 2024

She has deep knowledge in Immunology and T cell biology, and 13 years of experience in Research (seven of them in biotech at Immunocore), including pipeline programme leadership.

Engineering 81

Engineering Clinical Trials Therapies Cell Biology 81

Broad Institute

NOVEMBER 2, 2023

We've been using those for a long while, for modeling various aspects of biology like genomic variation, experimental artifacts, single-cell biology, and other areas. Generative AI is something that has been brewing for a long time in the machine learning community, going back to the fundamental tenets of Bayesian statistics.

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Research Engineering Science Cell Biology 124

The Pharma Data

FEBRUARY 24, 2022

Their findings are published online in Nature Cell Biology. “We are amazed by the efficiency of small-molecule PROTAC in simultaneously targeting EZH2 and cMyc in cancer cells.” cMyc is hard to ‘drug,'” Greg Wang said. MS177 targets both EZH2 and cMyc and thus inhibit cancer growth.

Small Molecule 52

Small Molecule Cell Biology Research Drug Development 52

Drug Target Review

JANUARY 31, 2024

This interest in seeing a drug or a device move successfully through various stages of development, from the research bench to the patient bedside has always been my North Star. I got into this field because I enjoy supporting the journey of a drug/device from beginning to end, resulting in optimal patient outcomes.

Clinical Trials 97

Clinical Trials Production Science Research 97

Drug Target Review

APRIL 9, 2024

Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects. More recently, the group has expanded to other areas such as mechanisms of drug resistance and neurodegenerative diseases.

RNA 64

RNA Cell Biology Clinical Development Disease 64

Drug Target Review

AUGUST 24, 2023

She joined the company in November 2018 with more than 10 years of experience in drug discovery and non-clinical development of immunomodulatory drugs in the immuno-oncology space. Shear forces induce ICAM-1 nanoclustering on endothelial cells that impact on T-cell migration. Current Opinion in Cell Biology.

Treatment 98

Treatment Therapies Clinical Development Cell Biology 98

Alta Sciences

JANUARY 31, 2025

It owned the societal name of the Canadian Association for Research on Drug Safety. As experts in early-phase drug development , from discovery through Phase II clinical research , we at Altasciences can share with STC members our accumulated knowledge and experience, and provide mentorship for future toxicologists.

Cell Biology 52

Cell Biology Pharmaceutical Companies Clinical Research Government 52

Drug Target Review

AUGUST 10, 2023

When bound to GRP78, ID2 loses its inhibitory function, leading to increased invasiveness of cancer cells. Implications for cancer therapeutics and beyond These findings have wide-ranging implications for cancer treatment and cell biology research.

Cell Biology 52

Cell Biology Small Molecule Regulations Engineering 52

DrugBank

JUNE 27, 2023

The general notion is that patients should be viewed individually, rather than strictly as members of some larger general population, and that their specific genetic background, environment, and lifestyle choices should be considered throughout drug development to the point of treatment and continuing patient care.

Disease 98

Disease Treatment Drugs Clinical Trials 98

Drug Target Review

JULY 31, 2023

The goals for Sunesis had such an impact on my current research, as did the early days of thinking about what we call fragment-based drug discovery. Thus, you don’t have to find a molecule that fills that whole interface, which is much larger than a drug-like molecule. The idea of undrugability is really a tautology.

DNA 98

DNA Science Small Molecule Cell Biology 98

Drug Target Review

DECEMBER 21, 2023

Dr Susanne Rafelski, who led the study, spoke with Drug Target Review about how the study was conducted, how it might apply to diseases and future directions. SR: This project started in the early days of the Allen Institute for Cell Science, nearly seven years ago. Can you give a brief overview of your research methods?

International 105

International Science Disease Research 105

KIF1A

MAY 24, 2023

The approach often focuses the patient-voice around a common goal of treatment, be it to inform a clinical endpoint or identify patient demographics for a drug treatment. One approach is to target common entities in the therapeutic development process such as regulatory agencies, established clinicians, and biopharmaceutical companies.

Disease 98

Disease Laboratories Research Science 98

The Pharma Data

JANUARY 4, 2021

05, 2021 (GLOBE NEWSWIRE) — Innate Pharma SA (Euronext Paris: IPH – ISIN: FR0010331421; Nasdaq: IPHA) (“ Innate ” or the “ Company ”) today announced that Sanofi has made the decision to progress IPH6101/SAR443579 into investigational new drug (IND)-enabling studies. Cell 2019 ). . MARSEILLE, France, Jan.

Drugs 40

Drugs Cell Biology Pharmacokinetics Clinical Trials 40

Dark Matter Blog

APRIL 4, 2023

The bulk of my nearly three decades of experience up to that point was with drugging protein targets using a variety of modalities, but principally small molecules. It’s all well and good to say, “we should drug RNA,” but which RNA? Prior to 2015, I had a casual relationship, at best, with targeting RNA. Welcome to the RNA world.

Small Molecule 52

Small Molecule RNA Fragment Screening DNA 52

Drug Target Review

MAY 21, 2024

I don’t think that it’s harder for women to enter careers in STEM, at least not in the scientific field—cell biology—that I have predominantly worked in. Organoids are poised to completely overhaul the drug discovery process. Organoids are being used in more and more clinical trials.

Doctors 59

Doctors Science Research Cell Biology 59

The Pharma Data

JANUARY 3, 2021

Dr. Zeldis, who formerly served as Chief Medical Officer (CMO) and Head of Clinical Research, Medical Affairs, and Drug Safety, at Celgene, and CEO of Celgene Global Health, helped guide Celgene’s expansion into one of the biotechnology industry’s most successful companies.

Immune Response 40

Immune Response Clinical Trials Therapies Cell Biology 40

Drug Target Review

JANUARY 30, 2024

Cell Transplant. It enhanced morphine-induced MOR endocytosis via GRK2/β-arrestin2 pathway. This also provides solid theoretical basis to treat morphine tolerance. References Mercadante S, Arcuri E, Santoni A. Opioid-Induced Tolerance and Hyperalgesia. 2019;33(10):943-55. Historical Review: Opiate Addiction and Opioid Receptors.

Treatment 52

Treatment Doctors Cell Biology Regulations 52

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

That’s good news for the future development of drugs designed to target those receptors ever more precisely, getting them to work better and with fewer side effects. 2] G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs? 2018 Jun;558(7711):553-558. [2] Many Targe Sriram K, Insel PA.

Laboratories 52

Laboratories Research Drugs Regulations 52

BMG Labtech

MARCH 9, 2023

Mitochondrial toxicity can occur when drugs or diseases affect the mitochondria and prevent the proper production of energy. Read, how to measure it with plate readers.

Disease 52

Disease Production Drugs Cell Biology 52

Drug Target Review

MAY 22, 2023

Dr Susanne Rafelski, who led the study, spoke with Drug Target Review about how the study was conducted, how it might apply to diseases, and future directions. This project started in the early days of the Allen Institute for Cell Science, nearly seven years ago. Can you give a brief overview of your research methods?

International 59

International Science Disease Research 59

Codon

APRIL 9, 2024

sweet wormwood), from which artemisinin, the antimalarial drug, was first isolated. Artemisinin-based drugs work by causing Plasmodium proteins to unfold and by inhibiting new proteins from folding properly, which eventually destroys the parasite. ’s Good Manufacturing Practice standards for drug production.

Drugs 139

Drugs Science Research Doctors 139

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Drug Target Review

JUNE 5, 2023

Can you tell us more about ZW191 and its potential as an FRα-targeting antibody-drug conjugate? ZW191 is comprised of a novel fully humanised IgG1 antibody covalently conjugated to a novel topoisomerase 1 inhibitor ZD06519, a camptothecin derivative, via endogenous interchain cysteines with a drug-to-antibody ratio (DAR) of eight.

Treatment 100

Treatment Pharmacokinetics Drugs Cell Biology 100

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. They are used to treat cancers including melanoma and non-small cell lung cancer, but work only for a small fraction of patients.

Research 137

Research Immune Response Clinical Trials Therapies 137

The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g.

Cell Biology 52

Cell Biology Molecular Biology Science Research 52

Drug Target Review

OCTOBER 2, 2024

Cardiovascular diseases are the leading cause of mortality worldwide, and traditional approaches like drug therapy or invasive procedures manage symptoms but do not restore lost cardiac tissue. Continued growth in the field relies on multidisciplinary efforts combining biology, engineering, and clinical medicine.

Therapies 98

Therapies Disease Engineering RNA 98

PerkinElmer

JANUARY 21, 2022

By repurposing existing translational drugs and developing new treatments, researchers hope they will be able to delay the onset of neurodegenerative conditions. Gallacher said that researchers need to identify and then measure biomarkers for disease, so they can then identify what changes over time. “By

Cell Biology 52

Cell Biology Disease Treatment Science 52

Drug Target Review

JUNE 29, 2023

Looking back, at the way we approach safety in preclinical testing and in IND (investigation new drug) submissions was really changed by those papers. Because we are using cells as medicines, they’re living medicines that we hope that they become cancer treatments where it’s literally one dose and you’re done.

Therapies 115

Therapies Science Production Cell Biology 115

Drug Target Review

DECEMBER 21, 2023

Where do you see the future of mRNA biology and AI converging, and how does Anima Biotech plan to lead this convergence? mRNA biology has become widely recognised as a new “drug mine” RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer.

Disease 105

Disease Small Molecule Vaccine Drugs 105

NIH Director's Blog: Drug Discovery

APRIL 11, 2017

Not only does this discovery raise hope for better treatments for many parasitic and bacterial diseases, it highlights the value of screening peptides in the search for ways to treat conditions that do not respond well—or have stopped responding—to more traditional chemical drug compounds. All of their hard work came up empty. Nat Commun.

Small Molecule 52

Small Molecule Science Drug Development Disease 52

The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. And third, the company is accelerating its transformation and further increasing efficiency. In addition to further strengthening its U.S.

Science 52

Science Pharmaceuticals Licensing Licensing 52

Codon

OCTOBER 22, 2024

In another instance, a detailed analysis carried out by Science shows how research on the fake drug Cerebrolysin became much more popular after a series of fraudulent papers were published by a relatively famous neuroscientist.

Science 110

Science Research Government Cell Biology 110