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New machine learning-based single-cell search engine makes cell annotation faster, more efficient

Broad Institute

Scientists then annotate the cells with this information, a process that can take days or even weeks, depending on the number of cells being labeled, and requires labor-intensive literature and database searches. We wanted to build a tool like that for cell biology. It’s basically a search engine.

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Applications of engineered exosomes in drugging noncoding RNAs for cancer therapy

Chemical Biology and Drug Design

Exosome engineering can be conducted through surface and content modification of biological exosomes. In preisolation method, parental cells are stimulated to express some special genes like lncRNAs, miRNAs, and receptors to have the capacity to bind to the target cells and deliver their content.

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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98
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Patient-derived organoids in disease modelling

Drug Target Review

Two-dimensional cell models were the cornerstone of cellular assays in early drug discovery for years, yet the system lacks the genetic and epigenetic background of the patient and the cell-to-cell spatial architecture and cellular signalling between cells of different types within the tissue architecture.

Disease 122
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Q&A: How generative AI could help accelerate biomedical research

Broad Institute

At the Broad Institute of MIT and Harvard, a group of researchers, software engineers, administrators, and communicators (yes, us) has been exploring the use of these chatbots and similar tools, surveying the community and developing recommendations. So you have to do your own fact-checking.

Research 124
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Breakthrough drug candidates and cancer treatment innovations

Drug Target Review

ZW191 is an antibody-drug conjugate (ADC) that is engineered to target folate receptor-⍺ (FR⍺), a protein that has limited expression in normal tissues but is often elevated on a variety of tumours including epithelial ovarian, endometrial, triple negative breast and lung adenocarcinoma.

Treatment 100
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CAR-NK cells: promising for cancer therapy

Drug Target Review

She obtained her PhD from the University of Wollongong in 2015 and gained extensive research experience as a postdoctoral fellow at Swinburne University of Technology, CSIRO, and Monash University, in the fields of immunology and tissue engineering.

Therapies 118