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New machine learning-based single-cell search engine makes cell annotation faster, more efficient

Broad Institute

Scientists then annotate the cells with this information, a process that can take days or even weeks, depending on the number of cells being labeled, and requires labor-intensive literature and database searches. We wanted to build a tool like that for cell biology. It’s basically a search engine.

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Fast Biology

Codon

My search made me appreciate how remarkable it is that life functions at all, considering the chaotic conditions in which cells exist. It also gave me a new appreciation for biology, and the incredible exactitude that one must have to engineer it — let alone engineer it successfully. of a Boeing 737 jet engine.

RNA 98
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Cell and gene therapy development moves into cardiac indications

Drug Target Review

The heart does have limited regenerative capacity, but not enough of the healthy cells that capable of restoring function, making it difficult to recover from injuries such as myocardial infarction. However, cell-based therapies are intended to leverage those healthy cells via transplant to regenerate damaged tissue.

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A research team searches for every gene that helps tumors evade immunotherapy

Broad Institute

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. These cells also express the Cas9 protein, which helps disable the genes targeted by the guide RNAs.

Research 137
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Women in STEM with Juliet Williams

Drug Target Review

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. With these newer programs, I’ve had the honour of collaborating with my team to build a multi-faceted drug discovery engine.

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Codon Digest: CAR-T Therapy for Neuroblastoma

Codon

LanzaTech announced a partnership with H&M Move to convert factory carbon emissions into fabrics using engineered microbes. Stem cells from macaques were converted into synthetic embryos, and then those embryos were implanted back into eight different female macaques. RNA may offer a safer form of pest control in the future.

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Cancer metastasis: breakthrough in therapeutic strategies

Drug Target Review

Researchers from the Keck School of Medicine of USC used imaging techniques to study how the protein GRP78 controls cancer cell behavior. In the top row, human lung cancer cells were engineered to over-express GRP78 in the nucleus. In the bottom row, cells lacked GRP78 in the nucleus.