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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.

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Women in STEM with Juliet Williams

Drug Target Review

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. With these newer programs, I’ve had the honour of collaborating with my team to build a multi-faceted drug discovery engine.

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Cancer metastasis: breakthrough in therapeutic strategies

Drug Target Review

Researchers from the Keck School of Medicine of USC used imaging techniques to study how the protein GRP78 controls cancer cell behavior. In the top row, human lung cancer cells were engineered to over-express GRP78 in the nucleus. In the bottom row, cells lacked GRP78 in the nucleus.

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Women in STEM July: Meet Michelle Arkin

Drug Target Review

I went to Genentech and postdoc-ed for Jim Wells in protein engineering. If you are collaborating with all of these different people, if you’re providing the small molecule tools for lots of different projects, how can I evaluate you as an independent scientist?” That was a very hot field and a really exciting area.

DNA 98
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AM-Pharma Appoints Chief Medical Officer and VP Manufacturing to Support Global Pivotal Trial in Sepsis-associated Acute Kidney Injury

The Pharma Data

At Aduro, he was responsible for all manufacturing and supply chain activities for the company’s biologics and small molecules and managed a transatlantic team. Earlier in his career, he held development and engineering positions at BAC, part of Life Technologies, Unilever, and Crucell. in Cell Biology from Utrecht University.

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Codon Digest: Injected Gene Editors

Codon

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Thanks for skimming. Gungabeesoon J.

DNA 52
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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) How to make a cell-penetrating Cas9 protein, and then incubate it with peptides to edit human cells. 2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Nature Biomedical Engineering.

Vaccine 52