Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. The team found that deleting the gene Ptpn2 made tumors sensitive to PD-1 therapy, and they published their findings in Nature in 2017.

Research 137

Research Immune Response Clinical Trials Therapies 137

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) How to make a cell-penetrating Cas9 protein, and then incubate it with peptides to edit human cells. 2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Nature Biomedical Engineering.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) How to make a cell-penetrating Cas9 protein, and then incubate it with peptides to edit human cells. 2/ Live Long and Prosper, Lil’ Yeasty Boys Yeast cells usually live for about one week. Nature Biomedical Engineering.

Vaccine 52

Vaccine DNA Engineering RNA 52

Drug Target Review

JUNE 29, 2023

Can you tell us about your journey in the field of science, technology, engineering and maths (STEM) and the challenges you encountered along the way? I think the cell-therapy field has evolved a lot – and is continuing to do so – in the time I’ve been working with this. That’s how I was brought up.

Therapies 115

Therapies Science Production Cell Biology 115

Drug Target Review

JUNE 5, 2023

ZW191 is an antibody-drug conjugate (ADC) that is engineered to target folate receptor-⍺ (FR⍺), a protein that has limited expression in normal tissues but is often elevated on a variety of tumours including epithelial ovarian, endometrial, triple negative breast and lung adenocarcinoma.

Treatment 100

Treatment Pharmacokinetics Drugs Cell Biology 100

Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. With these newer programs, I’ve had the honour of collaborating with my team to build a multi-faceted drug discovery engine.

Small Molecule 115

Small Molecule Targeted Protein Degradation Science Disease 115

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Thanks for skimming. Gungabeesoon J.

DNA 52

DNA RNA Engineering Licensing 52

The Pharma Data

OCTOBER 22, 2020

INTERLINK-1 represents first Phase 3 study examining IO approach in R/M SCCHN patients who have been treatedwith a platinum-based therapy and PD-(L)1 inhibitor. Overall, the combination therapy data to date supports the expedited development of monalizumab and cetuximab in this indication. MARSEILLE, France, Oct.

Clinical Trials 40

Clinical Trials Trials Cell Biology Production 40

Codon

SEPTEMBER 22, 2024

They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days.

DNA 96

DNA Laboratories Regulations Therapies 96

SugarCone Biotech

MAY 28, 2019

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). Aren’t we just waking up exhausted T cells, or moving T cells from the tumor margin into the tumor bed?

Immune Response 52

Immune Response Therapies Engineering Drug Development 52

Codon

AUGUST 10, 2023

Credit: Bruce Wetzel and Harry Schaefer, NCI, NIH | License Progress in biology is arguably moving faster today than at any point in the course of human history. Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. Nature Reviews Molecular Cell Biology (2009).

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Credit: Bruce Wetzel and Harry Schaefer, NCI, NIH | License Last edit: 13 September 2023 Progress in biology is arguably moving faster today than at any point in the course of human history. Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. Nature (2005).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. epidermidis , can actually trigger tumor-specific T cells. In other words: Brush some engineered bacteria on the skin, and they activate the immune system to go fight a tumor. Nature Cell Biology.

Engineering 52

Engineering DNA RNA Science 52