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Cell and gene therapy development moves into cardiac indications

Drug Target Review

The heart does have limited regenerative capacity, but not enough of the healthy cells that capable of restoring function, making it difficult to recover from injuries such as myocardial infarction. However, cell-based therapies are intended to leverage those healthy cells via transplant to regenerate damaged tissue.

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Codon Digest: Injected Gene Editors

Codon

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. ” — Samuel Butler , 1878 (* = My picks) AI + Bio Characterizing the interaction conformation between T-cell receptors and epitopes with deep learning. Thanks for skimming. Gungabeesoon J.

DNA 52
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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

It’s an easier way to get CRISPR into cells! Other methods to deliver Cas9 (like with viruses) are way less efficient, and seem to vary wildly from one cell to the next. Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer.

Vaccine 52
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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

It’s an easier way to get CRISPR into cells! Other methods to deliver Cas9 (like with viruses) are way less efficient, and seem to vary wildly from one cell to the next. Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer.

Vaccine 52
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Codon Digest: CAR-T Therapy for Neuroblastoma

Codon

LanzaTech announced a partnership with H&M Move to convert factory carbon emissions into fabrics using engineered microbes. Stem cells from macaques were converted into synthetic embryos, and then those embryos were implanted back into eight different female macaques. Read *Functional synthetic biology. Shrock E.L.

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Codon Digest: GPT-4 Controls a Robot

Codon

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. epidermidis , can actually trigger tumor-specific T cells. In other words: Brush some engineered bacteria on the skin, and they activate the immune system to go fight a tumor. Nature Cell Biology.

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On Prions and Protein Design

Codon

Experiments performed with the bacterium Streptococcus pneumoniae not only led to the discovery of DNA as the principal hereditary molecule but also yielded early tools for genetic engineering. The study of RNA tumor viruses revealed reverse transcriptase , an enzyme integral in studying RNA biology. Subscribe to Asimov Press.

RNA 89