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Patient-derived organoids in disease modelling

Drug Target Review

They self-assemble and in doing so retain the genetics, structure and heterogeneity of cell types found in the tissue they derive from. Their close resemblance to the patient and disease state makes PDOs a valuable and scalable source of biological material to interrogate in disease research and drug discovery.

Disease 122
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Who are the AACR Scientific Achievement Award winners?

Drug Discovery World

The American Association for Cancer Research (AACR) will honour the following cancer researchers, physician-scientists, advocates, and journalists during its annual meeting to be held April 14-19 at the Orange County Convention Center in Orlando, Florida. June’s award lecture will be held on Sunday April 16 at 4:30pm ET.

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Researchers reveal regenerative potential of the thymus

Drug Discovery World

Researchers have identified stem cells in the human thymus for the first time, representing a potential new target to understand immune diseases and cancer. The thymus is a gland located in the front part of the chest, the place where thymocytes (the cells in the thymus) mature into T cells.

Research 147
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NexImmune Strengthens Scientific Leadership by Appointing Jerome Zeldis as EVP R&D and Jeffrey Weber as Chief Scientific Advisor

The Pharma Data

We are very honored to have someone of Dr. Zeldis’ caliber lead our scientific research and clinical development teams. Both Jerry and Jeff have proven and successful track records in the design and execution of early and late-stage clinical trials that have evaluated novel immune therapies. . GAITHERSBURG, Md.,

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A research team searches for every gene that helps tumors evade immunotherapy

Broad Institute

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. They are used to treat cancers including melanoma and non-small cell lung cancer, but work only for a small fraction of patients.

Research 137
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CAR-NK cells: promising for cancer therapy

Drug Target Review

NK cells are among the front line of protection from infected and abnormal cells as part of the ‘innate immune response’. They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells).

Therapies 118
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Research Roundup: Different Antibody Responses to COVID-19 and More

The Pharma Data

Researchers at Stanford Medicine found that COVID-19 antibodies preferentially target different parts of the SARS-CoV-2 virus in mild COVID-19 cases than they do in severe cases. Antibody responses are not likely to be the sole determinant of someone’s outcome,” said Scott Boyd, associate professor of pathology at Stanford.