Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. They are used to treat cancers including melanoma and non-small cell lung cancer, but work only for a small fraction of patients.

Research 137

Research Immune Response Clinical Trials Therapies 137

Drug Target Review

OCTOBER 16, 2023

This is particularly pertinent in immune-based cell therapies like CAR-T, where animals do not mimic the human immune response. Nikki drives adoption of 3D cellular models of human disease by applying her expertise in cell biology to drug discovery and high-throughput screening.

Disease 122

Disease Immune Response Cell Biology Treatment 122

Drug Target Review

NOVEMBER 17, 2023

NK cells are among the front line of protection from infected and abnormal cells as part of the ‘innate immune response’. They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells).

Therapies 118

Therapies Clinical Trials Cell Biology Trials 118

The Pharma Data

JANUARY 3, 2021

He brings extensive life sciences experience to the Company, gained primarily through his nearly 20-year career at Celgene where he built the medical infrastructure as the company evolved. The backbone of NexImmune’s approach is its proprietary Artificial Immune Modulation (AIM TM ) nanoparticle technology platform.

Immune Response 40

Immune Response Clinical Trials Therapies Cell Biology 40

The Pharma Data

DECEMBER 31, 2020

“Antibody responses are not likely to be the sole determinant of someone’s outcome,” said Scott Boyd, associate professor of pathology at Stanford. Some of these patients mount a vigorous immune response, and others have a more moderate response. There are also other branches of the immune system involved.

Research 52

Research Virus Immune Response Cell Biology 52

Codon

APRIL 9, 2023

“Computer science is to biology what calculus is to physics.” Read Basic Science *mRNA decoding in human is kinetically and structurally distinct from bacteria. Read Germline-encoded amino acid–binding motifs drive immunodominant public antibody responses. Science Translational Medicine.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

APRIL 30, 2023

But if you start to play with the times during which these genes are expressed, you can make cells age differently. Often, when we engineer a cell, we only mess with the magnitude of an effect; this study suggests that we should think more about the timing, too. Read more at Science. Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52