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NK cells are among the front line of protection from infected and abnormal cells as part of the ‘innate immuneresponse’. They recognise ‘cell stress molecules’ on the surface of infected, old, injured and cancerous cells without the need for complex pre-stimulation signals of the adaptive immune system (eg, T cells).
Cell and gene therapies (CGTs) have made significant advancements in treating oncological diseases, with therapies like CAR-T cell treatments transforming cancer care. However, cell-based therapies are intended to leverage those healthy cells via transplant to regenerate damaged tissue.
By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cellbiology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. His mother had a presentation of the disease that suggested her immune system was already on the job.
This is particularly pertinent in immune-based celltherapies like CAR-T, where animals do not mimic the human immuneresponse. The full potential of PDOs would be to shorten the time and costs associated with medicine creation, and then use PDO therapies to treat patients effectively.
“Computer science is to biology what calculus is to physics.” ” — Harold Morowitz 🔥 Ten Amazing Things (that happened this week…) A CAR-T therapy was tested in 27 children with neuroblastomas. The CAR-T cells were detectable in 26 out of 27 children after 30 months. Molecular Therapy.
Both Jerry and Jeff have proven and successful track records in the design and execution of early and late-stage clinical trials that have evaluated novel immunetherapies. .
GAITHERSBURG, Md.,
In one experiment, the microneedle patches were used to deliver a SARS-CoV-2 vaccine into mice, producing immuneresponses similar to a traditional injection. Printed vaccines caused mice to have a faster immuneresponse. Nature CellBiology. difficile therapy. But the printed vaccines are very good!
In one experiment, the microneedle patches were used to deliver a SARS-CoV-2 vaccine into mice, producing immuneresponses similar to a traditional injection. Printed vaccines caused mice to have a faster immuneresponse. Nature CellBiology. difficile therapy. But the printed vaccines are very good!
Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance celltherapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). Aren’t we just waking up exhausted T cells, or moving T cells from the tumor margin into the tumor bed?
This looks like an early step toward a much different future for biology: One in which natural language is used to design experiments, program robots, and automate experiments in high-throughput. Skin microbes can trigger strong immuneresponses. epidermidis , can actually trigger tumor-specific T cells. Nature Protocols.
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