Drug Target Review

OCTOBER 2, 2024

Viral vectors, such as adeno-associated viruses (AAVs), are commonly used to deliver therapeutic genes to cardiac cells. RNA-based therapies, including mRNA and RNA interference (RNAi), are being explored to modulate gene expression in heart cells. Allogeneic cell therapies must avoid immune rejection.

Therapies 98

Therapies Disease RNA Engineering 98

The Pharma Data

DECEMBER 31, 2020

Researchers at Stanford Medicine found that COVID-19 antibodies preferentially target different parts of the SARS-CoV-2 virus in mild COVID-19 cases than they do in severe cases. The spike protein binds to the ACE2 receptor on human cells, which allows the virus to enter the cell.

Research 52

Research Virus Immune Response Cell Biology 52

Codon

APRIL 30, 2023

This works for many different cell types, and the method can also be used to deliver several different gene editors at once. It’s an easier way to get CRISPR into cells! Other methods to deliver Cas9 (like with viruses) are way less efficient, and seem to vary wildly from one cell to the next. Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

This works for many different cell types, and the method can also be used to deliver several different gene editors at once. It’s an easier way to get CRISPR into cells! Other methods to deliver Cas9 (like with viruses) are way less efficient, and seem to vary wildly from one cell to the next. Nature Cell Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 9, 2023

Read Rational design of a highly immunogenic prefusion-stabilized F glycoprotein antigen for a respiratory syncytial virus vaccine. Read An engineered HIV-1 Gag-based VLP displaying high antigen density induces strong antibody-dependent functional immune responses. Nature Cell Biology. McGrady N.R. Gene Therapy.

Therapies 52

Therapies RNA Engineering Vaccine 52

SugarCone Biotech

MAY 28, 2019

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). Fc-hacking immune responses. This ‘‘cloaking’’ mechanism thus limits neutrophil activation.

Immune Response 52

Immune Response Therapies Engineering Drug Development 52

Codon

APRIL 16, 2023

This looks like an early step toward a much different future for biology: One in which natural language is used to design experiments, program robots, and automate experiments in high-throughput. Skin microbes can trigger strong immune responses. epidermidis , can actually trigger tumor-specific T cells. Cell Reports.

Engineering 52

Engineering DNA RNA Science 52