Drug Target Review

APRIL 9, 2024

In a previous study, we showed that these peptides decorate all cellular RNAs and thus impair the binding of RNA-binding proteins to RNA. Initial works from the lab concentrated on exploring the role of replicative stress in cancer and ageing, for which the group combined cell biology, mouse models and drug development projects.

RNA 64

RNA Cell Biology Clinical Development DNA 64

Codon

APRIL 2, 2023

A giant dataset about the rat brain, and how neurons connect to each other, was collected and pooled together from 20 different research laboratories. Read A new DNA polymerase variant, called RT-KTq I614Y, can directly detect RNA modifications, including pseudouridine (Ψ) and queuosine (Q). Communications Biology.

DNA 52

DNA RNA Engineering Licensing 52

Drug Discovery World

NOVEMBER 13, 2023

Michael Traxlmayr, PhD, Group leader, CD Laboratory for Next-Generation CAR T Cells, University of Natural Resources & Life Sciences, on: ‘Novel concepts to regulate CAR T cell activity with small molecule drugs in vivo’.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Codon

APRIL 9, 2023

Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. Nature Chemical Biology. Current Biology.

Therapies 52

Therapies RNA Engineering Vaccine 52

Drug Discovery World

OCTOBER 20, 2022

A limitation of conventional flow cytometry in the era of single cell biology is how many distinct pieces of information can be collected about each cell. Mass Cytometry: Single Cells, Many Features. Elyada et al. 2016;165(4):780-791. doi:10.1016/j. 2016.04.019. About the author.

Cell Based Assays 130

Cell Based Assays Therapies Cell Biology RNA 130

Codon

SEPTEMBER 22, 2024

How Eggs and Sperm Get Made In the laboratory where I work, just down the street from the bustling Fenway Park in Boston, there is an incubator with a 96-well plate inside. Each well in the plate contains an ovarian organoid, a clump of cells similar to a miniature ovary. Sign up for Asimov Press.

DNA 97

DNA Laboratories Regulations Engineering 97

Codon

APRIL 16, 2023

Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read An RNA-based system to study hepatitis B virus replication and evaluate antivirals. Nature Biotechnology.

Engineering 52

Engineering DNA RNA Science 52