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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.

Disease 98
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New molecular insights on medical cannabis

Drug Target Review

Recently, our laboratory discovered a potent partial inhibition of ATX by cannabinoids in a nanomolar range. Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. Umezu-Goto M, Kishi Y, Taira A, et al. 2017;2017:1–15.

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Codon Digest: Injected Gene Editors

Codon

A giant dataset about the rat brain, and how neurons connect to each other, was collected and pooled together from 20 different research laboratories. An open-source FACS automation system for high-throughput cell biology. Cell Systems. “Human cells hacked to act like squid skin cells could unlock key to camouflage.”

DNA 52
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On Prions and Protein Design

Codon

Experiments performed with the bacterium Streptococcus pneumoniae not only led to the discovery of DNA as the principal hereditary molecule but also yielded early tools for genetic engineering. The study of RNA tumor viruses revealed reverse transcriptase , an enzyme integral in studying RNA biology. Subscribe to Asimov Press.

RNA 62
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What is Protein Nitration? | BMG LABTECH

BMG Labtech

The introduction of a nitro- group into a protein molecule is also implicated in different diseases including cardiovascular disease , lung disease, diabetes, cancer and some neurodegenerative conditions. The nitration of proteins can significantly modify both the structural and catalytic roles of these molecules. The assay (Fig.

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Codon Digest: GPT-4 Controls a Robot

Codon

Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Read Postdocs who work in an HHMI laboratory now get a minimum salary of $70,000. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Biotechnology. Nature Protocols.