Drug Target Review

APRIL 9, 2024

Our approach to investigate the toxicity driven by nucleolar stress was to induce it with certain arginine-rich peptides, present in patients of ALS, which were known to accumulate at nucleoli and cause this type of stress. These compounds were later licensed to the pharmaceutical industry for clinical development.

RNA 64

RNA Cell Biology Clinical Development Disease 64

The Pharma Data

DECEMBER 1, 2020

All corporate information, such as the Company’s financial statements and corporate presentations, is available on [link] v estors.innate-pharma.com. Innate Pharma’s commercial-stage product, Lumoxiti, in-licensed from AstraZeneca in the US, EU and Switzerland, was approved by the FDA in September 2018.

Cell Biology 52

Cell Biology Clinical Trials Production Licensing 52

The Pharma Data

OCTOBER 22, 2020

Presented at the ESMO 2019 Congress, the combination of monalizumab and cetuximab demonstrated a manageable safety profile and a response rate of 27.5% (36% and 17% in IO-naïve, n=22, and IO-pretreated patients, n=18, respectively). Lumoxiti is a first-in class specialty oncology product for hairy cell leukemia.

Clinical Trials 40

Clinical Trials Trials Cell Biology Production 40

The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. Last year alone, the company concluded more than 25 collaboration and licensing agreements and acquisitions in its Pharmaceuticals Division.

Science 52

Science Pharmaceuticals Licensing Licensing 52

Codon

APRIL 2, 2023

This paper presents a massive CRISPR screen, in Arabidopsis, that identifies many genes with previously "hidden functions." The authors tested 59,000+ gRNAs, each targeting 2-10 genes, and ultimately identified a new type of transporter protein in the plant cells. An open-source FACS automation system for high-throughput cell biology.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 16, 2023

epidermidis , can actually trigger tumor-specific T cells. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study. Nature Cell Biology.

Engineering 52

Engineering DNA RNA Science 52

Codon

AUGUST 10, 2023

Credit: Bruce Wetzel and Harry Schaefer, NCI, NIH | License Progress in biology is arguably moving faster today than at any point in the course of human history. Engineered biology has profound potential to change how we live, but the field has become broad, bloated, nebulous. Nature Reviews Molecular Cell Biology (2009).

DNA 98

DNA Cell Biology Molecular Biology Engineering 98