Dark Matter Blog

APRIL 4, 2023

The tools in this kit fall into a few broad categories: understanding protein structures and their functional significance, identifying ligands that bind into functionally significant pockets, and developing assays that confirm target engagement along with demonstrating the anticipated impact on cell biology.

Small Molecule 52

Small Molecule RNA Fragment Screening DNA 52

Codon

APRIL 9, 2024

However, the blandly clinical package of artemisinin and artesunate tablets reveals little about how the key compound was first discovered. When Louis Miller, now Chief of Malaria Cell Biology at the NIH, attended a malaria conference in Shanghai in 2008, he asked: Who discovered artemisinin? Nobody had an answer.

Drugs 139

Drugs Science Research Doctors 139

Codon

APRIL 2, 2023

Read Inhalable nanoparticles, packaged with mRNA or CRISPR systems, efficiently edit lung cells. They achieved high gene-editing efficiencies in airway epithelial cells (which are normally hard to target.) Read A really simple way to isolate AAVs, which are a type of virus often used to deliver gene therapies into cells.

DNA 52

DNA RNA Engineering Licensing 52

Codon

NOVEMBER 1, 2024

Molecular biology has only been around for about 80 years, and tools to study biomolecules (such as DNA and RNA sequencing, or proteomics) have only existed for about half of that time. We are in the absolute infancy of molecular and cell biology, and this means there’s a lot of stuff we still don’t understand.

DNA 122

DNA RNA Molecular Biology Laboratories 122