Drug Target Review

APRIL 9, 2024

Our approach to investigate the toxicity driven by nucleolar stress was to induce it with certain arginine-rich peptides, present in patients of ALS, which were known to accumulate at nucleoli and cause this type of stress. However, our study was first to show that inducing nucleolar stress in an adult mammal accelerates aging.

RNA 65

RNA Cell Biology Clinical Development Disease 65

The Pharma Data

OCTOBER 27, 2021

million expansion will bring high quality seeds to worldwide markets faster, providing solutions for growers and meeting consumer demands / The seven-hectare global Product Design Center in San Nicolás includes state-of-the-art lab space for cell biology research and greenhouses for seed production.

Cell Biology 40

Cell Biology Production Laboratories Marketing 40

Alta Sciences

JANUARY 31, 2025

It was such an enriching experience to connect with the invited speakers and learn about their work, as well as meet graduate students at their poster presentations. At the 2024 meeting, I had the honor and pleasure of being a Scientific Program Committee industry member.

Cell Biology 52

Cell Biology Pharmaceutical Companies Clinical Research Government 52

The Pharma Data

DECEMBER 1, 2020

All corporate information, such as the Company’s financial statements and corporate presentations, is available on [link] v estors.innate-pharma.com. Innate has been a pioneer in the understanding of natural killer cell biology and has expanded its expertise in the tumor microenvironment and tumor-antigens, as well as antibody engineering.

Cell Biology 52

Cell Biology Clinical Trials Production Licensing 52

DrugBank

JUNE 27, 2023

” 4 The term originally rose to prominence after the completion of the Human Genome Project 5 as a call to action in the face of wide disparities between treatment outcomes within the same clinical presentation; however, the exact meaning has changed as technology continues to advance. 53 , 1527–1533 (2021).

Disease 98

Disease Treatment Drugs Clinical Trials 98

Drug Target Review

JANUARY 30, 2024

Considering the translational potential of this research to clinical applications, what are the key preclinical findings that present the 3A5C7 monoclonal antibody as a promising therapeutic option for managing morphine tolerance in humans?

Treatment 52

Treatment Doctors Cell Biology Regulations 52

The Pharma Data

OCTOBER 22, 2020

Presented at the ESMO 2019 Congress, the combination of monalizumab and cetuximab demonstrated a manageable safety profile and a response rate of 27.5% (36% and 17% in IO-naïve, n=22, and IO-pretreated patients, n=18, respectively).

Clinical Trials 40

Clinical Trials Trials Cell Biology Production 40

New Drug Approvals

JANUARY 9, 2024

The present invention is directed to methods of preparation of compound of formula (I) that is useful for inhibiting Cyclin-dependent kinase 7 (CDK7) and for treating diseases or disorders mediated thereby. Recent genetic and biochemical studies have confirmed the importance of CDK7 for cell cycle progression (Larochelle.

Production 62

Production DNA RNA Regulations 62

Codon

APRIL 9, 2024

Titled “Discovery of Antimalarial Chinese Herbal Medicine Under the Guidance of Mao Zedong’s Thoughts,” her presentation reported the 100 percent efficacy rate of the sample crude ether neutral extract from qinghao in both rodent and simian (primate) malaria experiments. WRAIR had discovered A. annua in Washington, D.C.

Drugs 139

Drugs Science Research Doctors 139

Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. His mother had a presentation of the disease that suggested her immune system was already on the job.

Research 137

Research Immune Response Clinical Trials Therapies 137

The Pharma Data

MARCH 16, 2022

The Bayer Foundation has presented the Hansen Family Award, complete with its prize money of EUR 75,000, to Professor Kai Johnsson. using SNAP-tag) involves labeling cell proteins with a fluorescent dye, thereby enabling researchers to observe how proteins interact in the living cell and where in the cell they are located.

Cell Biology 52

Cell Biology Molecular Biology Science Research 52

Drug Target Review

OCTOBER 2, 2024

Still, the high cost of CGTs, driven by their complexity and individualised nature, presents barriers to widespread adoption in cardiology, limiting patient access. Autologous cell therapies, which involve extracting, manipulating, and reinfusing a patient’s own cells, are resource-intensive and expensive.

Therapies 98

Therapies Disease Engineering RNA 98

Codon

OCTOBER 22, 2024

Still, shortly after I read Mastroianni’s article, Ben Recht asked on Twitter if there were any articles presenting “a positive case for peer review.” In my own experience with peer review, most of the changes reviewers requested had to do with improving the writing and presentation of ideas.

Science 110

Science Research Government Cell Biology 110

The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. And third, the company is accelerating its transformation and further increasing efficiency.

Science 52

Science Pharmaceuticals Licensing Licensing 52

The Pharma Data

MARCH 25, 2022

. “With the help of advanced laboratory techniques, we were able to identify a panel of nanobodies that very effectively neutralized several variants of SARS-CoV-2,” says Gerald McInerney, professor at the Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, and joint senior author of both studies.

Molecular Biology 52

Molecular Biology Laboratories Cell Biology Science 52

BMG Labtech

MARCH 8, 2023

For instance, intermediates of the TCA cycle are present in all known organisms from unicellular bacteria to complex and large multicellular organisms like elephants. 10 Metabolism is evidently perturbed in different diseases like cancer, diabetes, and metabolic syndrome.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Broad Institute

JULY 28, 2023

Thyroid hormone is, like glucocorticoids, a nuclear hormone with transcription-factor receptors present in adult (both mouse and human) cortex. in molecular and cell biology and biochemistry from the University of Oxford.

Medical Schools 52

Medical Schools Hospitals Regulations Research 52

Codon

APRIL 2, 2023

This paper presents a massive CRISPR screen, in Arabidopsis, that identifies many genes with previously "hidden functions." The authors tested 59,000+ gRNAs, each targeting 2-10 genes, and ultimately identified a new type of transporter protein in the plant cells. An open-source FACS automation system for high-throughput cell biology.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. Read The F.D.A.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. Read The F.D.A.

Vaccine 52

Vaccine DNA Engineering RNA 52

Drug Target Review

AUGUST 7, 2023

As macrophages are present in all organs, including the brain, targeting these “tissue-resident macrophages” with appropriate drugs may offer a way to slow down age-related neurodegenerative diseases. This impairment in calcium signalling leads to chronic inflammation, which is associated with a host of age-related ailments.

Disease 98

Disease Cell Biology Research Drugs 98

Drug Target Review

APRIL 1, 2025

I then took over management of a research group, initially running cell biology research and then preclinical development.” Dan then took over management of a cell research group, initially running a cell biology research project then preclinical development.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Codon

APRIL 16, 2023

This was no small feat, because moths respond to a complex mixture of two or three different molecules that must be present at specific ratios. Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Nature Biotechnology. coli DNA using a Retro-Cascorder.

Engineering 52

Engineering DNA RNA Science 52

Drug Target Review

JANUARY 16, 2025

5 New computational models of strain present opportunities for designing lower-strain bound conformations 16 and, combined with conventional CADD methods for assessing binding interactions with a protein, guide the optimisation of high-affinity macrocycles. Ajay N Jain Ajay is VP of Research for the Optibrium s BioPharmics Division.

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

SugarCone Biotech

MAY 28, 2019

Two talks given at SITC 2019 session set me thinking about the quality of immune cell interactions, the outcomes for the interacting cells and the implications for cancer immunotherapy. These talks, by Ron Germain and Michael Dustin, presented the lives of immune cells in a series of diverse locations with a complex cast of characters.

Immune Response 52

Immune Response Therapies Engineering Drug Development 52

BMG Labtech

FEBRUARY 24, 2025

Detecting nitrated tyrosine residues in these assays presents challenges due to the complexities in accurately quantifying and identifying these specific modifications in proteins.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52