Drug Target Review

NOVEMBER 1, 2023

Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. The Journal of Cell Biology. Pleotropic Roles of Autotaxin in the Nervous System Present Opportunities for the Development of Novel Therapeutics for Neurological Diseases. 2002 Jul 22;158(2):227–33.

Clinical Trials 134

Clinical Trials Trials Small Molecule Disease 134

Codon

APRIL 2, 2023

This paper presents a massive CRISPR screen, in Arabidopsis, that identifies many genes with previously "hidden functions." The authors tested 59,000+ gRNAs, each targeting 2-10 genes, and ultimately identified a new type of transporter protein in the plant cells. An open-source FACS automation system for high-throughput cell biology.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Cell Systems.

Vaccine 52

Vaccine DNA Engineering RNA 52

Drug Target Review

JANUARY 16, 2025

Traditionally, drug discovery has focused on small-molecule therapeutics, typically with a molecular weight of less than 500 Daltons. 2 Typically, small-molecule drugs target active sites buried inside proteins. What are macrocycles and why are they interesting for drug discovery?

Drug Development 52

Drug Development Small Molecule Drugs FDA Approval 52

Codon

APRIL 16, 2023

This was no small feat, because moths respond to a complex mixture of two or three different molecules that must be present at specific ratios. Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. Nature Biotechnology. Nature Protocols.

Engineering 52

Engineering DNA RNA Science 52

BMG Labtech

FEBRUARY 24, 2025

Detecting nitrated tyrosine residues in these assays presents challenges due to the complexities in accurately quantifying and identifying these specific modifications in proteins. In the highlighted study, the CLARIOstar Plus was used to detect peroxynitrite during phagocytosis with a small molecule sensor. The assay (Fig.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52