Drug Target Review

JULY 23, 2024

Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. I carried that appetite for knowledge, coupled with a driven work ethic, through my graduate and post-graduate studies at the University College London.

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BMG Labtech

MARCH 9, 2023

Mitochondrial toxicity can occur when drugs or diseases affect the mitochondria and prevent the proper production of energy. Read, how to measure it with plate readers.

Disease 52

Disease Production Drugs Cell Biology 52

The Pharma Data

JANUARY 3, 2021

Both will help NexImmune advance current early-stage clinical trials and will guide Company’s translational efforts to develop new immunotherapy products. The AIM technology enables NexImmune to construct nanoparticles that function as synthetic dendritic cells capable of directing a specific T cell-mediated immune response.

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Immune Response Clinical Trials Therapies Cell Biology 40

The Pharma Data

JANUARY 4, 2021

About the Innate-Sanofi agreement: The Company has a research collaboration and licensing agreement with Sanofi to apply Innate’s proprietary technology to the development of innovative multispecific antibody formats engaging natural killer (NK) cells to kill tumor cells and secrete cytokines through the activating receptor NKp46.

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Drugs Cell Biology Pharmacokinetics Clinical Trials 40

The Pharma Data

OCTOBER 22, 2020

Innate Pharma’s commercial-stage product, Lumoxiti, in-licensed from AstraZeneca in the US, EU and Switzerland, was approved by the FDA in September 2018. Lumoxiti is a first-in class specialty oncology product for hairy cell leukemia. About Innate Pharma: Innate Pharma S.A.

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Clinical Trials Trials Cell Biology Production 40

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

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Production DNA RNA Regulations 62

DrugBank

JUNE 27, 2023

Coding mutations have a more direct effect through direct alteration of a gene product. Network expansion of genetic associations defines a pleiotropy map of human cell biology. Genetic variation can also be classified into “coding” and “non-coding” mutations. 53 , 1527–1533 (2021).

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Codon

APRIL 9, 2024

’s Good Manufacturing Practice standards for drug production. When Louis Miller, now Chief of Malaria Cell Biology at the NIH, attended a malaria conference in Shanghai in 2008, he asked: Who discovered artemisinin? and China, as well as misunderstandings between TDR and China on the intentions of the collaboration.

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Broad Institute

OCTOBER 11, 2023

By Allessandra DiCorato October 11, 2023 In 2011, Robert Manguso was working in a cell biology lab when his mother was diagnosed with Merkel cell carcinoma, a rare and aggressive skin cancer. When I began my PhD I completely switched my focus, and I haven’t looked back,” said Manguso.

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Drug Target Review

OCTOBER 2, 2024

RNA-based therapies, including mRNA and RNA interference (RNAi), are being explored to modulate gene expression in heart cells. For instance, mRNA therapies can promote the production of specific proteins required for heart tissue repair, while RNAi can silence harmful gene expression, such as those driving fibrosis in heart failure.

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Drug Target Review

JUNE 29, 2023

And actually, what drives products to the clinic is more doing things that are good enough to get them done within time and to a budget is actually better than focusing on perfection. If you don’t ever make commercial products, then you haven’t really fulfilled the potential you have.

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Therapies Science Production Cell Biology 116

The Pharma Data

MARCH 16, 2022

The research scientist at the Max Planck Institute for Medical Research received the award in recognition of his ground-breaking work in establishing various approaches to protein labeling in living cells that have enabled far-reaching advances in chemical and cell biology. Protein labeling (e.g.

Cell Biology 52

Cell Biology Molecular Biology Science Research 52

PerkinElmer

JANUARY 21, 2022

Accelerating Capabilities for Dementia Biomarker Discovery To achieve that goal, the Dementia Platform’s focus involves studying the disease from many points of view – from lifestyle, age, and cognitive function, to genetics, cell biology, and phenotypic screening.

Cell Biology 52

Cell Biology Disease Treatment Science 52

The Pharma Data

MARCH 11, 2021

Second, the biorevolution is driving innovation in all of Bayer’s divisions – with major progress in cell biology, gene editing and data science. Beyond 2021 numerous product introductions are planned, including several hundred new corn, soybean and vegetable varieties each year. through 2023.

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Science Pharmaceuticals Licensing Licensing 52

BMG Labtech

MARCH 8, 2023

This coordinated series of biochemical reactions where the product of one conversion becomes the substrate for another reaction is known as metabolic pathways. Metabolism also includes the disposal of waste and by-products. In the cell, these macromolecules are synthesized in a step-by-step process from simple precursors.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Precision for Medicine

APRIL 7, 2023

Our new state-of-the-art laboratory, combined with the deep knowledge of our scientists, gives an advantage to clients developing novel therapeutics and diagnostic products in oncology, liver disease, and skin diseases. This service accelerates the validation of these products and helps shorten the time for regulatory approvals.

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Laboratories Clinical Research Clinical Trials Cell Biology 52

Codon

OCTOBER 22, 2024

10 The established experts at the helm of peer review may be resistant to accepting paradigm-shifting work, but they also help us suss out blind alleys and steer research in more productive directions. ” — Calvin McCarter New researchers can benefit a great deal from peer review for two primary reasons.

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Drug Target Review

DECEMBER 21, 2023

There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype. And since mRNA biology is like the highway of cell biology, it would likely be visible there. And this is exactly where AI can provide us with an extremely powerful new strategy.

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Disease Small Molecule Vaccine Drugs 106

Broad Institute

JULY 28, 2023

metabolic products or byproducts secreted by the candidate probiotics) can reverse an early life stress-induced susceptibility phenotype in adult mice and whether these changes are associated with transcriptional alterations in the brain. in molecular and cell biology and biochemistry from the University of Oxford.

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Medical Schools Hospitals Regulations Research 52

Codon

APRIL 2, 2023

An open-source FACS automation system for high-throughput cell biology. They make meatballs using “molecular engineering;” the meat products include myoglobin proteins based on the DNA sequence of extinct mammoths. “10 women founders taking the synthetic biology world by storm.” Might be useful!

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 9, 2023

Read A roadmap to establish a comprehensive platform for sustainable manufacturing of natural products in yeast. Read Algal cell bionics as a step towards photosynthesis-independent hydrogen production. Read Synthetic biology for plant genetic engineering and molecular farming. Nature Cell Biology.

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Therapies RNA Engineering Vaccine 52

Codon

SEPTEMBER 22, 2024

Today, we’re launching Issue 04 with this essay about the future of fertility and in vitro oogenesis — a technology that could soon be used to convert human skin cells into eggs or sperm — by one of its foremost developers. Thanks for reading. This multi-month method matches the duration of germline commitment in vivo.

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DNA Laboratories Regulations Therapies 117

Drug Target Review

APRIL 1, 2025

I then took over management of a research group, initially running cell biology research and then preclinical development.” ” ASOs are already under trial at University College London Hospital for Alzheimers, targeting the production of the Tau protein. From there, Dan moved to Meatable as the Chief Product Officer.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Codon

APRIL 16, 2023

Nature Cell Biology. Read *Open-endedness in synthetic biology: a route to continual innovation for biological design. ACS Synthetic Biology. Read Easy modular integrative fuSion-ready Expression (Easy-MISE) toolkit for fast engineering of heterologous productions in Saccharomyces cerevisiae. ACS Synthetic Biology.

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Engineering DNA RNA Science 52

Drug Target Review

JANUARY 16, 2025

9,10 Because many therapeutic macrocycles violate the Ro5 guidelines, the presumption was that such large molecules would have limited cell permeability. 11 Macrocycles can also be engineered in other ways to become more cell permeable; for example, by incorporating N-methyl groups in macrocyclic peptides.

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Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

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DNA Cell Biology Molecular Biology Engineering 98

Codon

APRIL 8, 2025

Take ATP synthase, the molecular motor that creates fuel molecules for the cell. We know from direct observation that it functions like a nanoscale rotary engine , with its central shaft spinning as it converts energy from proton flow into ATP production.

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RNA DNA Laboratories Virus 95

BMG Labtech

FEBRUARY 24, 2025

Protein nitration assays are widely used in many research areas including but not limited to biochemistry , biotechnology , cell biology , microbiology , and molecular biology. Increased peroxynitrite production by myeloid derived suppressor cells has been observed in the tumor microenvironment of many cancer patients.

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Small Molecule Disease Licensing Licensing 52

Drug Target Review

MARCH 26, 2025

3 The scalable production of oestrogen led to its popularity and by the 1980-1990s, oestrogen (Premarin) was named the number one drug prescribed in the US. Hydrogels as delivery systems Hydrogels are three-dimensional networks of aqueous polymers that have been used in biotechnology products, specifically medical devices, since the 1960s.

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Therapies Compliance Treatment Small Molecule 52

SugarCone Biotech

MAY 28, 2019

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). I note in passing that their analyses suggest that strategies aimed at the CD39/CD73/A2AR pathway may have limited clinical impact.

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Immune Response Therapies Engineering Drug Development 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

NOVEMBER 1, 2024

Molecular biology has only been around for about 80 years, and tools to study biomolecules (such as DNA and RNA sequencing, or proteomics) have only existed for about half of that time. We are in the absolute infancy of molecular and cell biology, and this means there’s a lot of stuff we still don’t understand.

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