The Pharma Data

JANUARY 23, 2021

Collagen density regulates the activity of tumor-infiltrating T cells Kuczek, D.E., Particularly in TNBC, collagen remodeling is seen in the stromal compartment [ 3 ]. Assessing Collagen Features at a Finer Level of Detail. References. Larsen, A.M.H., Thorseth, ML. immunotherapy cancer 7, 68 (2019).

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Treatment Cell Biology Hospitals Clinical Trials 52

BMG Labtech

NOVEMBER 21, 2023

Effectors of signal transmission events Second messengers are small molecules or ions that transmit signals received at the cell surface to the inside environment of the cell (Fig.

Small Molecule 40

Small Molecule Regulations Research Cell Biology 40

NIH Director's Blog: Drug Development

SEPTEMBER 20, 2018

That includes those involved in regulating our appetites and our moods, via a class of G proteins known as inhibitory G proteins (G i ). They share a common architecture and bind a relatively limited number of intracellular signaling proteins called G proteins.

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Laboratories Research Regulations Drugs 52

DrugBank

JUNE 27, 2023

14 As an unbiased method for genetic variant detection, GWAS holds the promise of identifying new genes and gene regulation mechanisms underlying a variety of conditions, including complex diseases. Network expansion of genetic associations defines a pleiotropy map of human cell biology. 53 , 1527–1533 (2021).

Disease 98

Disease Treatment Drugs Clinical Trials 98

New Drug Approvals

JANUARY 9, 2024

As such, it has been proposed that inhibiting CDK7 would provide a potent means of inhibiting cell cycle progression, which may be especially relevant given that there is compelling evidence from gene knockout studies in mice for lack of an absolute requirement for CDK2, CDK4 and CDK6 for the cell cycle at least in most cell types (M alumbres et al.,

Production 62

Production DNA RNA Regulations 62

Drug Target Review

JUNE 29, 2023

It set a precedent with regulators as to what is expected in some instances. Because we are using cells as medicines, they’re living medicines that we hope that they become cancer treatments where it’s literally one dose and you’re done.

Therapies 115

Therapies Science Production Cell Biology 115

Broad Institute

JULY 28, 2023

Our pilot study will span: 1) high-resolution EM (electron microscopy) of synaptic excitatory-inhibitory (E-I) balance and nearby glial cells; 2) functional electrophysiological signatures of altered E-I balance by sex in ACC brain slices; 3) molecular correlates of these impairments that can be targeted for recovery of function.

Medical Schools 52

Medical Schools Hospitals Regulations Research 52

Drug Target Review

DECEMBER 21, 2023

mRNA biology has become widely recognised as a new “drug mine” RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer. There must be something different in those diseased cells, some dysregulated pathway that is causing that disease phenotype.

Disease 105

Disease Small Molecule Vaccine Drugs 105

BMG Labtech

MARCH 8, 2023

Cell metabolism and disease Metabolic perturbations and metabolic reprogramming are associated with common human diseases. In fact, metabolism should not be considered as a self-regulating entity that is independent of other biological pathways. On the contrary, cell metabolism affects or is affected by a multitude of processes.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

APRIL 2, 2023

An open-source FACS automation system for high-throughput cell biology. Cell Systems. Read Small-molecule aptamer for regulating RNA functions in mammalian cells and animals. Read A general, deep learning tool to segment “ambiguous” biological images and datasets. Might be useful! Wiener D.M.

DNA 52

DNA RNA Engineering Licensing 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. .” Synthetic Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. A new paper engineers a communication network between cells using DNA instead. .” Synthetic Biology.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 9, 2023

Read Probe-based bacterial single-cell RNA sequencing predicts toxin regulation. Current Biology. ACS Synthetic Biology. A programmable and red light-regulated CRISPR-dCas9 system for the activation of endogenous genes in Saccharomyces cerevisiae. ACS Synthetic Biology. Nature Cell Biology.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

SEPTEMBER 22, 2024

They achieved this by treating mouse fetal ovaries with an enzyme mixture to break them apart into single cells, isolating the ovarian supporting cells, and mixing them with human PGC-like cells to form aggregates, which were then cultured in liquid media for up to 120 days.

DNA 117

DNA Laboratories Regulations Therapies 117

Codon

APRIL 16, 2023

Read Deep learning of genomic contexts predicts protein co-regulation and function. Cell Reports. Read RIP-PEN-seq identifies a class of kink-turn RNAs as splicing regulators. Nature Cell Biology. Rea Chromatin context-dependent regulation and epigenetic manipulation of prime editing. BMC Bioinformatics.

Engineering 52

Engineering DNA RNA Science 52

Drug Target Review

APRIL 1, 2025

I then took over management of a research group, initially running cell biology research and then preclinical development.” “Scientists now better understand how gene expression is regulated, leading directly to the development of ASOs that can target specific mutated genes,” Williams adds.

Disease 52

Disease Therapies Clinical Trials Cell Biology 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Broad Institute

NOVEMBER 21, 2024

said study senior author Brad Bernstein , an institute member at Broad and director of the Gene Regulation Observatory at Broad. “We We found that IDH mutations are like a ticking time bomb that allows brain tumor cells to grow slowly and hide from the immune system while they acquire more dangerous mutations. Nature Cancer.

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Research Medical Schools DNA Hospitals 124

BMG Labtech

FEBRUARY 24, 2025

Post-translational modification of proteins, which includes the alteration of certain amino acid side chains by the introduction of different chemical groups, takes place in eukaryotic and prokaryotic cells. For example, it may result in changes to cell metabolism or lead to alterations in crucial signaling events.

Small Molecule 52

Small Molecule Disease Licensing Licensing 52

SugarCone Biotech

MAY 28, 2019

Learnings regarding immune geography and cell:cell contact are increasingly important as we consider how best to advance cell therapies for diverse hematologic malignancies and solid tumors ( www.aletabio.com ). The immune system is tightly regulated and unkind to inappropriate signals. Fc-hacking immune responses.

Immune Response 52

Immune Response Therapies Engineering Drug Development 52

Codon

AUGUST 10, 2023

Nature Reviews Molecular Cell Biology (2009). Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). . & Weiss R.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

NOVEMBER 1, 2024

Molecular biology has only been around for about 80 years, and tools to study biomolecules (such as DNA and RNA sequencing, or proteomics) have only existed for about half of that time. We are in the absolute infancy of molecular and cell biology, and this means there’s a lot of stuff we still don’t understand.

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