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Condensate biology: advancing drug discovery for complex diseases

Drug Target Review

The aim is to establish condensate biology as a fundamental branch of cell biology – “cell biology 2.0” The underlying biology and processes upon which the company was founded have broad applicability across various human disease areas. Klein notes the importance of Dewpoint’s disease-agnostic approach.

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Cancer metastasis: breakthrough in therapeutic strategies

Drug Target Review

Metastasis is the most lethal attribute of cancer cells and clinical decisions regarding treatment are based largely upon the likelihood of developing metastases. 1 The research, supported by the National Institutes of Health, centres on a cellular chaperone protein called GRP78, responsible for regulating protein folding within cells.

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Role of second messengers in the cell | BMG LABTECH

BMG Labtech

Effectors of signal transmission events Second messengers are small molecules or ions that transmit signals received at the cell surface to the inside environment of the cell (Fig.

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The future of mRNA biology and AI convergence

Drug Target Review

mRNA biology has become widely recognised as a new “drug mine” RNAi drugs are in the market and mRNA vaccines, initially developed for Covid-19, are already in trials for cancer. All of these are novel targets to be explored in small molecule drug discovery as well as for improving the efficacy of mRNA vaccines.

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What to expect from PEGS Europe 2023: Day 3

Drug Discovery World

Michael Traxlmayr, PhD, Group leader, CD Laboratory for Next-Generation CAR T Cells, University of Natural Resources & Life Sciences, on: ‘Novel concepts to regulate CAR T cell activity with small molecule drugs in vivo’.

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Codon Digest: Injected Gene Editors

Codon

An open-source FACS automation system for high-throughput cell biology. Cell Systems. Read Small-molecule aptamer for regulating RNA functions in mammalian cells and animals. Read The FDA is reviewing a “controversial cell therapy for ALS,” developed by BrainStorm Cell Therapeutics.

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Codon Digest: Vaccine Printer Go Brrrrr!

Codon

Read Stem cells were induced to form insulin-secreting pancreas cells and then transplanted into diabetic mice, where they successfully restored glucose levels. Nature Cell Biology. Read Microbes in the wild ‘talk’ to their neighbors by emitting, and sensing, small chemicals. Synthetic Biology.

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